Cyclocytidine HCl

製品コードS1973 バッチS197302

化学情報

	Synonyms	NSC 145668 HCl	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₉H₁₂ClN₃O₄
	分子量	261.66	CAS No.	10212-25-6
Solubility (25°C)*	体外	Water	52 mg/mL warmed with 50ºC water bath (198.73 mM)
		DMSO	10 mg/mL warmed with 50ºC water bath (38.21 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
in vitro	Cyclocytidine HCl (Ancitabine) is the prodrug of cytarabine, which is structurally similar to human deoxycytidine to be incorporated into human DNA and then kills the cell. Cyclocytidine most affects rapidly dividing cells, which require DNA replication for mitosis. Cyclocytidine also inhibits both DNA and RNA polymerases and nucleotide reductase enzymes needed for DNA synthesis. ^[1]
in vivo	Cyclocytidine is a potent immunosuppresant, antiviral and antitumor agent in animals and man, maximum inhibitor effects require the use of complex injection schedules. ^[2]Cyclocytidine provides treatment for leukemia. ^[3]

プロトコル(参考用のみ)

動物実験	動物モデル	BDF1 mice inoculated L1210 cells
	投薬量	20 or 100 mg/kg/day
	投与方法	i.p. or s.c.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors [ Transl Oncol, 2023, 35:101712]	PubMed: 37354638
Cyclocytidine hydrochloride inhibits the synthesis of relaxed circular DNA of hepatitis B virus [ PeerJ, 2022, 10:e13719]	PubMed: 35846878
Inhibitory effect of cyclocytidine hydrochloride on vesicular stomatitis virus infection. [ Acta Biochim Biophys Sin (Shanghai), 2020, 14 pii: gmaa017]	PubMed: 32289151
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447]	PubMed: 30900754
Yeast-Based Screen to Identify Natural Compounds with a Potential Therapeutic Effect in Hailey-Hailey Disease. [ Int J Mol Sci, 2018, 19(6)]	PubMed: 29925776

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。