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Synonyms | Firefly luciferin, Beetle Luciferin | Storage (From the date of receipt) |
3 years -20°C(in the dark) powder | |
化学式 | C11H8N2O3S2 |
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分子量 | 280.32 | CAS No. | 2591-17-5 | |
Solubility (25°C)* | 体外 | DMSO | 56 mg/mL (199.77 mM) | |
Ethanol | 1 mg/mL (3.56 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications. In an immunocompetent mouse model of ovarian cancer, the use of D-luciferin substrate and firefly luciferase preserves tumour-host immune interactions since bioluminescent imaging is a more sensitive indication of tumour growth than weight gain. |
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in vitro | 1.Example protocol for in vitro bioluminescent image assays |
in vivo | In an immunocompetent mouse model of ovarian cancer, use of D-luciferin substrate and firefly luciferase preserves tumor-host immune interactions, since bioluminescent imaging is a more sensitive indication of tumor growth than weight gain. [2] |
細胞アッセイ | 細胞株 | ID8 cells |
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濃度 | 3000 μg/ml | |
反応時間 | ||
実験の流れ | ||
動物実験 | 動物モデル | Female BALB/c nu/nu mice |
投薬量 | 75 mg/kg | |
投与方法 | s.c. |
Carbenoxolone disodium suppresses the migration of gastric cancer by targeting HDAC6 [ Future Med Chem, 2023, 15(4):333-344] | PubMed: 36946221 |
Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis [ Cell Rep, 2022, 41(10):111742] | PubMed: 36476873 |
A magneto-controlled biocatalytic cascade with a fluorescent output [ Org Biomol Chem, 2022, 20(9):1869-1873] | PubMed: 35156979 |
Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer [ Cancer Res, 2021, 81(3):552-566] | PubMed: 33229341 |
Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy [ Breast Cancer Res, 2021, 23(1):11] | PubMed: 33485378 |
KDM4A-mediated histone demethylation of SLC7A11 inhibits cell ferroptosis in osteosarcoma [ Biochem Biophys Res Commun, 2021, 550:77-83] | PubMed: 33689883 |
Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer [ Cancer Res, 2020, canres.0617.2020] | PubMed: 33229341 |
Tumor treating fields increases membrane permeability in glioblastoma cells [ Cell Death Discov, 2018, 4:113] | PubMed: 30534421 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。