Dexamethasone Sodium Phosphate

製品コードS4028 バッチS402802

化学情報

	Synonyms	Dexamethasone 21-phosphate disodium salt	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₂H₃₀FO₈P.2Na
	分子量	516.4	CAS No.	55203-24-2
Solubility (25°C)*	体外	Water	100 mg/mL (193.64 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
in vitro	Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. ^[1] Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. ^[2]Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. ^[3] Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression. ^[5]
in vivo	Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. ^[4] Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats. ^[5]
特徴	Great selectivity for COX-2.

プロトコル(参考用のみ)

動物実験	動物モデル	Sprague-Dawley rats
	投薬量	100 μg/kg
	投与方法	Intraperitoneal injection

参考

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カスタマーフィードバック

: Data from [Oncogene, 2013, 32, 1316-29]

: Data from [Oncogene, 2013, 32, 1316-29]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Enhanced Differentiation Capacity and Transplantation Efficacy of Insulin-Producing Cell Clusters from Human iPSCs Using Permeable Nanofibrous Microwell-Arrayed Membrane for Diabetes Treatment [ Pharmaceutics, 2022, 14(2)400]	PubMed: 35214135
Dexamethasone Sensitizes Acute Monocytic Leukemia Cells to Ara-C by Upregulating FKBP51 [ Front Oncol, 2022, 12:888695]	PubMed: 35860568
Ponatinib sensitizes myeloma cells to MEK inhibition in the high-risk VQ model [ Sci Rep, 2022, 12(1):10616]	PubMed: 35739276
Establishing a clinically relevant orthotopic xenograft model of patient-derived glioblastoma in zebrafish [ Dis Model Mech, 2022, dmm.049109]	PubMed: 35199829
PON2 blockade overcomes dexamethasone resistance in acute lymphoblastic leukemia [ Hematology, 2022, 27(1):32-42]	PubMed: 34957927
CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma [ Mol Cancer, 2021, 20(1):84]	PubMed: 34090465
A universal gene correction approach for FKRP-associated dystroglycanopathies to enable autologous cell therapy [ Cell Rep, 2021, 36(2):109360]	PubMed: 34260922
Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression [ JCI Insight, 2021, 6(19)e147038]	PubMed: 34622799
Comprehensive CRISPR-Cas9 screens identify genetic determinants of drug responsiveness in multiple myeloma [ Blood Adv, 2021, 5(9):2391-2402]	PubMed: 33950175
Resveratrol attenuates dapagliflozin-induced renal gluconeogenesis via activating the PI3K/Akt pathway and suppressing the FoxO1 pathway in type 2 diabetes [ Food Funct, 2021, 10.1039/d0fo02387f]	PubMed: 33432947

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。