Dexrazoxane

製品コードS5651 バッチS565102

化学情報

	Synonyms	ICRF-187	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₁₁H₁₆N₄O₄
	分子量	268.27	CAS No.	24584-09-6
Solubility (25°C)*	体外	DMSO	54 mg/mL (201.28 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.
in vitro	Topoisomerase 2 (Top2) inhibition with dexrazoxane combined with dBET6 in HeLa cells increases DNA damage signaling at proximal time points.^[1]
in vivo	Dexrazoxane prevents doxorubicin induced late-onset cardiomyopathy and also protected the cardiac mitochondria from acquired ultrastructural, genetic and functional damage.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HeLa cells
	濃度	50 μM J60
	反応時間	4 h
	実験の流れ	HeLa cells are treated with 50 μM dexrazoxane for 4 h. Cell lysates are used for detecting the levels of BRD4, RNAPIIpS2 and γH2AX by western blots.
動物実験	動物モデル	Wistar rats (11 weeks of age)
	投薬量	8 mg/kg
	投与方法	i.p.

参考

[1] Edwards DS, et al. Cell Rep. 2020 Sep 22;32(12):108166.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity [ Biol Direct, 2023, 18(1):63]	PubMed: 37807075
Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity [ Biol Direct, 2023, 18(1):63]	PubMed: 37807075
Curcumin Analog, HO-3867, Induces Both Apoptosis and Ferroptosis via Multiple Mechanisms in NSCLC Cells with Wild-Type p53 [ Evid Based Complement Alternat Med, 2023, 2023:8378581]	PubMed: 36814470
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258]	PubMed: 35207746
Establishment and characterization of NCC-UPS4-C1: a novel cell line of undifferentiated pleomorphic sarcoma from a patient with Li-Fraumeni syndrome [ Hum Cell, 2022, 10.1007/s13577-022-00671-y]	PubMed: 35118583
Establishment and characterization of NCC-MFS4-C1: a novel patient-derived cell line of myxofibrosarcoma [ Hum Cell, 2021, 34(6):1911-1918]	PubMed: 34383271
Establishment and characterization of novel patient-derived cell lines from giant cell tumor of bone [ Hum Cell, 2021, 10.1007/s13577-021-00579-z]	PubMed: 34304386
Establishment and characterization of the NCC-GCTB4-C1 cell line: a novel patient-derived cell line from giant cell tumor of bone [ Hum Cell, 2021, 10.1007/s13577-021-00639-4]	PubMed: 34731453
BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation [ Cell Rep, 2020, 32(12):108166]	PubMed: 32966794
Doxorubicin-induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes [ J Cell Mol Med, 2019, 23(7):4627-4639]	PubMed: 31106979

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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