DHBP dibromide

製品コードS3700 バッチS370001

化学情報

	Synonyms	1,1'-diheptyl-4,4'-bipyridinium dibromide	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₄H₃₈N₂.2Br
	分子量	514.38	CAS No.	6159-05-3
Solubility (25°C)*	体外	DMSO	100 mg/mL (194.4 mM)
		Water	100 mg/mL (194.4 mM)
		Ethanol	100 mg/mL (194.4 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	DHBP (1,1'-diheptyl-4,4'-bipyridinium), a viologen for electrochromic memory display agent, inhibits the calcium release induced by 2 mM caffeine and 2 μg/ml polylysine with an IC50 value of 5 μg/ml and 4 μg/ml respectively.
in vitro	DHBP is a putative inhibitor of ryanodine receptors (RyRs). It is an attractive water-soluble, cell-permeable and reversible experimental probe to understand the role of RyR's in cellular processes. DHBP (10-50 μM) significantly inhibits RyR-mediated Ca2+ release from sarcoplasmic reticulum (SR) in intact single fibers enzymatically isolated from murine flexor digitorum brevis (FDB) muscles. DHBP (10-50 μM) also inhibits SR Ca2+ release in ventricular epicardium of intact hearts^[1].

製品説明

DHBP (1,1'-diheptyl-4,4'-bipyridinium), a viologen for electrochromic memory display agent, inhibits the calcium release induced by 2 mM caffeine and 2 μg/ml polylysine with an IC50 value of 5 μg/ml and 4 μg/ml respectively.

in vitro

DHBP is a putative inhibitor of ryanodine receptors (RyRs). It is an attractive water-soluble, cell-permeable and reversible experimental probe to understand the role of RyR's in cellular processes. DHBP (10-50 μM) significantly inhibits RyR-mediated Ca2+ release from sarcoplasmic reticulum (SR) in intact single fibers enzymatically isolated from murine flexor digitorum brevis (FDB) muscles. DHBP (10-50 μM) also inhibits SR Ca2+ release in ventricular epicardium of intact hearts^[1].

プロトコル(参考用のみ)

参考

[1] Yuriana Aguilar-Sanchez, et al. Cell. 2017, 112(3): supplement 1, p161a-162a.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。