受注:045-509-1970 |
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Synonyms | Dicumarol | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C19H12O6 |
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分子量 | 336.29 | CAS No. | 66-76-2 | |
Solubility (25°C)* | 体外 | DMSO | 3 mg/mL (8.92 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Dicoumarol is a competitive NADPH quinone oxidoreductase (NQO1) inhibitor,and used as an anticoagulant by interfering with the metabolism of vitamin K. |
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Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice [ Acta Pharmacol Sin, 2023, 1-13.] | PubMed: 36697978 |
Internally Controlled and Dynamic Optical Measures of Functional Tumor Biology [ Anal Chem, 2023, 95(13):5661-5670] | PubMed: 36952386 |
Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells [ Toxicol Lett, 2023, 378:39-50] | PubMed: 36863539 |
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors Necrostatin-1 (Nec-1) and 7-Cl-O-Nec-1 (Nec-1s) are potent inhibitors of NAD(P)H: Quinone oxidoreductase 1 (NQO1) [ Free Radic Biol Med, 2021, 173:64-69] | PubMed: 34252539 |
A novel strategy for glioblastoma treatment by induction of noptosis, an NQO1-dependent necrosis [ Free Radic Biol Med, 2021, 166:104-115] | PubMed: 33600944 |
2-Methoxy-6-acetyl-7-methyljuglone (MAM) Induced Programmed Necrosis in Glioblastoma by Targeting NAD(P)H: Quinone Oxidoreductase 1 (NQO1) [ Free Radic Biol Med, 2020, 28;152:336-347] | PubMed: 32234332 |
NQO1 Is a Determinant for Cellular Sensitivity to Anti-Tumor Agent Napabucasin [ Am J Cancer Res, 2020, 1;10(5):1442-1454] | PubMed: 32509390 |
Inhibition of pyruvate dehydrogenase kinase‑1 by dicoumarol enhances the sensitivity of hepatocellular carcinoma cells to oxaliplatin via metabolic reprogramming [ Int J Oncol, 2020, 57(3):733-742] | PubMed: 32705170 |
Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death. [ Clin Cancer Res, 2019, 25(23):7162-7174] | PubMed: 31527169 |
Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells. [ PLoS One, 2017, 12(6):e0179672] | PubMed: 28617852 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。