Digoxin

製品コードS4290 バッチS429005

化学情報

	Synonyms	NSC 95100, 12β-Hydroxydigitoxin	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₄₁H₆₄O₁₄
	分子量	780.94	CAS No.	20830-75-5
Solubility (25°C)*	体外	DMSO	85 mg/mL (108.84 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

プロトコル(参考用のみ)

参考

[1] Katz A, et al. Proc Natl Acad Sci U S A. 2015, 112(44):13723-8.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs [ Gastroenterology, 2024, S0016-5085(24)00062-3]	PubMed: 38262581
Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction [ Autophagy, 2023, 19(6):1803-1820]	PubMed: 36588318
IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer [ EMBO J, 2023, e110620.]	PubMed: 36637036
Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer [ Cancer Res, 2023, 83(1):141-157]	PubMed: 36346366
Alternation of Organ-Specific Exposure in LPS-Induced Pneumonia Mice after the Inhalation of Tetrandrine Is Governed by Metabolizing Enzyme Suppression and Lysosomal Trapping [ Int J Mol Sci, 2022, 23(21)12948]	PubMed: 36361734
Establishment of a Drug Screening Model for Cardiac Complications of Acute Renal Failure [ Biomolecules, 2021, 11(9)1370]	PubMed: 34572583
The HIF-1α/p53/miRNA-34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization [ J Cell Mol Med, 2021, 10.1111/jcmm.16272]	PubMed: 33438362
The HIF-1α/p53/miRNA-34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization [ J Cell Mol Med, 2021, 25(3):1700-1711]	PubMed: 33438362
Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury. [ PLoS Pathog, 2020, 16;16(3):e1008341]	PubMed: 32176725
The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis [ J Lipid Res, 2020, 61(12):1617-1628]	PubMed: 32848049

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。