Diminazene Aceturate

製品コードS4104 バッチS410401

化学情報

	Synonyms	Diminazene diaceturate	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₄H₁₅N₇.2C₄H₇NO₃
	分子量	515.52	CAS No.	908-54-3
Solubility (25°C)*	体外	Water	103 mg/mL (199.79 mM)
		DMSO	19 mg/mL (36.85 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent.
in vitro	Diminazene is capable of inhibiting the P2 transporter activity and this activity is lost in one diminazene-adapted trypanosome line, this does not formally prove that TbAT1 transports diminazene, nor does it establish whether transporter in addition to P2 could be involved in diminazene uptake. Diminazene is rapidly accumulated through a single transporter in T. brucei brucei 427 with K_m value of 0.45 μM. [³H]Diminazene transport is also potently inhibited by pentamidine and adenosine, with K_i values of 0.21 μM and 0.25 μM, respectively. [3H]diminazene (2.5 μM) is clearly accumulated by yeast cells expressing TbAT1, with a rate of 0.0083 pmol/10⁷ cell/s, and this process is completely inhibited by the presence of 1 mM unlabeled diminazene aceturate. ^[1]
in vivo	Diminazene aceturate (3.5 mg/kg) appeares to be effective in the first treatment of horses and mules infected with T. evansi, parasites are cleared from the peripheral blood of horses on days 1 and 7 and mules on days 1 and 14. ^[2] Diminazene aceturate (DA) (7 mg/kg, i.m.) effectively clears the parasites from the blood of the infected treated dogs. ^[3]

プロトコル(参考用のみ)

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Identification and targeting of microbial putrescine acetylation in bloodstream infections [ bioRxiv, 2023, 2023.09.21.558834]	PubMed: 37790300
Identification and targeting of microbial putrescine acetylation in bloodstream infections [ bioRxiv, 2023, 10.1101/2023.09.21.558834]	PubMed: 37790300
Lactate Dehydrogenase as a Potential Therapeutic Drug Target to Control Babesia bigemina [ Front Cell Infect Microbiol, 2022, 12:870852]	PubMed: 35521220
Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways. [ Am J Physiol Lung Cell Mol Physiol, 2020, 10.1152/ajplung.00025.2020]	PubMed: 32160007

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。