Doxylamine Succinate

製品コードS4240 バッチS424001

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₇H₂₂N₂O.C₄H₆O₄
	分子量	388.46	CAS No.	562-10-7
Solubility (25°C)*	体外	DMSO	78 mg/mL (200.79 mM)
		Water	78 mg/mL (200.79 mM)
		Ethanol	78 mg/mL (200.79 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.
in vivo	The effects of doxylamine (as the succinate salt) on microsomal enzyme activity and serum thyroid hormone levels are examined in B6C3F1 mice following dietary exposure for 7 or 15 days (0, 40, 375, 750, or 1500 ppm in diet, expressed as free base doxylamine). The results suggest that doxylamine is a phenobarbital-type inducer of liver microsomal cytochrome P450 in B6C3F1 mice, and consistent with the hypothesis that doxylamine increases the activity of those hepatic enzymes involved in T4 metabolism.

製品説明

Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.

in vivo

The effects of doxylamine (as the succinate salt) on microsomal enzyme activity and serum thyroid hormone levels are examined in B6C3F1 mice following dietary exposure for 7 or 15 days (0, 40, 375, 750, or 1500 ppm in diet, expressed as free base doxylamine). The results suggest that doxylamine is a phenobarbital-type inducer of liver microsomal cytochrome P450 in B6C3F1 mice, and consistent with the hypothesis that doxylamine increases the activity of those hepatic enzymes involved in T4 metabolism.

プロトコル(参考用のみ)

参考

[1] Bookstaff RC, et al. Toxicol Appl Pharmacol, 1996, 141(2), 584-594.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Evidence for Specific Receptor-Mediated Toxicity of Pharmaceuticals in Aquatic Organisms Derived from Acute and Chronic Standard Endpoints [ Environ Toxicol Chem, 2021, 10.1002/etc.5018]	PubMed: 33595135

Evidence for Specific Receptor-Mediated Toxicity of Pharmaceuticals in Aquatic Organisms Derived from Acute and Chronic Standard Endpoints [ Environ Toxicol Chem, 2021, 10.1002/etc.5018]

PubMed: 33595135

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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