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Synonyms | Etamsylate | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C6H6O5S.C4H11N |
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分子量 | 263.31 | CAS No. | 2624-44-4 | |
Solubility (25°C)* | 体外 | DMSO | 53 mg/mL (201.28 mM) | |
Water | 53 mg/mL (201.28 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Ethamsylate (Etamsylate) is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion. |
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in vitro | Ethamsylate inhibits prostaglandin bio-synthesis in microsomes of pregnant human myometrium with IC50 of 0.5 mM. [1] Ethamsylate is particularly active against hydroxyl radicals (OH.), which are scavenged at therapeutic Ethamsylate concentrations (0.1–10 μM). Higher Ethamsylate concentrations are required to scavenge superoxide radicals. Ethamsylate potentiates human platelet aggregation and ATP release induced by arachidonic acid, thromboxane A2, collagen, and calcium ionophore A23187. [2] |
in vivo | Ethamsylate reduces the mean bleeding time when administered systemically or orally to rabbits. By the intravenous route, Ethamsylate reduces bleeding time by half at doses >5 mg/kg. The effect starts 5 minutes after the injection, reaches a maximum between 30 minutes and 4 hours after the injection, and disappears after 6 hours. By the oral route, a similar maximal action is observed at the dose of 10 mg/kg. The efficacy of Ethamsylate to reduce intraventricular hemorrhage is associated with a reduction of thromboxane A2 and prostacyclin biosynthesis. Orally given Ethamsylate (>25 mg/kg) also inhibits carrageenan-induced rat paw edema. [2] |
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長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。