受注:045-509-1970 |
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Synonyms | Zarontin | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C7H11NO2 |
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分子量 | 141.17 | CAS No. | 77-67-8 | |
Solubility (25°C)* | 体外 | DMSO | 28 mg/mL (198.34 mM) | |
Water | 28 mg/mL (198.34 mM) | |||
Ethanol | 28 mg/mL (198.34 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Ethosuximide(Zarontin) is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker. |
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in vitro | Ethosuximide(ETH) enhances hippocampal derived NSC proliferation and neurospheres formation in vitro. Low concentration of ETH induces proliferation of NSC, while higher concentrations of ETH are cytotoxic. Also, ETH activates the PI3K/Akt signal transduction pathway in adult hippocampal NSC in vitro. Blockade of the PI3K/Akt pathway inhibits ETH induced hippocampal NSC neuronal differentiation[3]. |
in vivo | Anti-epileptic drug ethosuximide rescues the short lifespan and chemosensory defects exhibited by C. elegans null mutants of dnj-14, the worm orthologue of the DNAJC5 gene mutated in autosomal-dominant adult-onset neuronal ceroid lipofuscinosis. It also ameliorates the locomotion impairment and short lifespan of worms expressing a human Tau mutant that causes frontotemporal dementia[1]. Ethosuximide extends lifespan by inhibiting the function of specific chemosensory neurons[2]. It increases neurogenesis, reduces neurodegeneration, and reverses cognitive impairments in rat model of AD like phenotypes[3]. |
細胞アッセイ | 細胞株 | Mouse neuroblastoma cell line (N2A) |
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濃度 | 0.1, 0.56, 1 mg/ml | |
反応時間 | 5 h | |
実験の流れ | Mouse Neuro2A (N2A) neuroblastoma cells are cultured on 6-well plates and treated with retinoic acid to induce neuronal differentiation. After 24 h, N2A cells are treated with vehicle control (PBS) or increasing concentrations of ethosuximide for 5 h. Total RNA is then isolated, DNase-treated and reverse transcribed to cDNA. qRT-PCR is run above normalising to the reference genes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin (ACTB). |
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動物実験 | 動物モデル | Adult Wistar rats |
投薬量 | 125 mg/kg | |
投与方法 | i.p. |
Data from [Data independently produced by , , Nature, 2018, 554(7692):317-322]
Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. [Yang Y, et al. Nature, 2018, 554(7692):317-322] | PubMed: 29446381 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。