Fluticasone propionate

製品コードS1992 バッチS199201

化学情報

	Synonyms	CCI-187881	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₅H₃₁F₃O₅S
	分子量	500.57	CAS No.	80474-14-2
Solubility (25°C)*	体外	DMSO	100 mg/mL (199.77 mM)
		Ethanol	5 mg/mL (9.98 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明	Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
in vitro	Fluticasone propionate (1 pM) inhibits the constitutive and TGF-beta-induced expression of alpha-SMA in human lung myofibroblasts. Fluticasone propionate blocks the TNF-alpha-induced nuclear translocation of the pro-inflammatory transcription factor NF-kappaB in human lung myofibroblasts. ^[1] Fluticasone propionate inhibits in lung myofibroblasts, at a very early stage of differentiation, the activation of Janus kinase/STAT pathways induced by IL-13 (tyrosine kinase 2, STAT1, STAT3, STAT6, mitogen-activated protein kinase). Fluticasone propionate still displays a potential anti-inflammatory activity even if it only inhibits tyrosine kinase 2 phosphorylation in mildly or fully differentiated myofibroblastic cultures. Fluticasone propionate inhibits constitutive and TGF-beta-induced expression of alpha-smooth muscle actin, the main marker of myofibroblastic differentiation, both in very early and in mild differentiated myofibroblasts. Fluticasone propionate displays an additional powerful anti-inflammatory effect, decreasing nuclear translocation of NF-kappaB independent of the degree of myofibroblastic differentiation. ^[2] Fluticasone propionate inhibits allergen-induced T-cell proliferation, expression of IL-3, IL-5 and GM-CSF mRNA, and secretion of the corresponding proteins in a concentration-dependent fashion. Fluticasone propionate has the potential markedly to inhibit allergen-induced T-cell production of asthma-relevant cytokines. ^[3]
in vivo	Fluticasone propionate administrated after induction of a severe heaves exacerbation results in complete resolution of clinical signs, normalization of pulmonary function tests, and significant decrease in bronchoalveolar lavage (BAL) neutrophilia in horse. ^[4]

プロトコル(参考用のみ)

参考

[4] Gigu鑢e S, et al. Vet Immunol Immunopathol,?002, 85(3-4), 147-158.

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging [ Cell Rep Methods, 2023, 3(4):100440]	PubMed: 37159662
Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging [ Cell Reports Methods, 2023, 10.1016/j.crmeth.2023.100440]	PubMed: None
Impact of Betamethasone Pretreatment on Engrafment of Cord Blood-Derived Hematopoietic Stem Cells [ Arch Immunol Ther Exp (Warsz), 2022, 71(1):1]	PubMed: 36528821
Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment. [ Nat Med, 2017, 23(4):424-428]	PubMed: 28263313

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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