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Synonyms | Natural heparin pentasaccharide Sodium, Fondaparin sodium, SR-90107A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C31H43N3O49S8.10Na |
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分子量 | 1728.08 | CAS No. | 114870-03-0 | |
Solubility (25°C)* | 体外 | Water | 100 mg/mL (57.86 mM) | |
DMSO | 60 mg/mL (34.72 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Fondaparinux Sodium (Org 31540, Natural heparin pentasaccharide, Fondaparin, SR-90107A) is a synthetic glucopyranoside with antithrombotic activity. It selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin; a synthetic inhibitor of Factor Xa. |
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in vitro | Fondaparinux is a synthetic pentasaccharide that selectively inhibits factor Xa (FXa) in the coagulation cascade. Fondaparinux has been shown to inhibit the TF-FVIIa complex and FIXa in vitro[1]. |
in vivo | Fondaparinux reduces kidney I/R injury primarily by inhibiting the recruitment of neutrophil. It dramatically reduced fibrin deposition in the kidney[1]. Fondaparinux can promote the stability of atherosclerotic lesions in apolipoprotein E-deficient mice, possibly through inhibiting expression of the inflammatory mediators in plaque and reduced synthesis of MMP-9 and MMP-13[2]. |
細胞アッセイ | 細胞株 | U937 cells |
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濃度 | 0-100 μg/ml | |
反応時間 | 30 min | |
実験の流れ | Fondaparinux was diluted in PBS to a total volume of 50 μL and added to the wells. Labeled U937 cells (50 μL) were then added and incubated at room temperature for 30 min. Finally, the wells were washed three times with PBS and cells were lyzed using 2% Triton X-100 in 0.1 mol/L Tris-HCl pH 9.5. |
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動物実験 | 動物モデル | Murine model of kidney I/R (background: C57BL/6) |
投薬量 | 5-10 mg/kg | |
投与方法 | i.p. |
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長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。