Ginkgolide C

製品コードS3781 バッチS378101

化学情報

	Synonyms	BN-52022	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₀H₂₄O₁₁
	分子量	440.40	CAS No.	15291-76-6
Solubility (25°C)*	体外	DMSO	88 mg/mL (199.81 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Ginkgolide C (BN-52022), isolated from Ginkgo biloba leaves, is a flavone reported to have multiple biological functions, from decreased platelet aggregation to ameliorating Alzheimer disease. It is an activator of MMP-9.
in vitro	Ginkgolide C significantly suppresses lipid accumulation in differentiated adipocytes. It also decreases adipogenesis-related transcription factor expression, including peroxisome proliferator-activated receptor and CCAAT/enhancer-binding protein. Furthermore, ginkgolide C enhances adipose triglyceride lipase and hormone-sensitive lipase production for lipolysis and increases phosphorylation of AMP-activated protein kinase (AMPK), resulting in decreased activity of acetyl-CoA carboxylase for fatty acid synthesis^[1].

製品説明

Ginkgolide C (BN-52022), isolated from Ginkgo biloba leaves, is a flavone reported to have multiple biological functions, from decreased platelet aggregation to ameliorating Alzheimer disease. It is an activator of MMP-9.

in vitro

Ginkgolide C significantly suppresses lipid accumulation in differentiated adipocytes. It also decreases adipogenesis-related transcription factor expression, including peroxisome proliferator-activated receptor and CCAAT/enhancer-binding protein. Furthermore, ginkgolide C enhances adipose triglyceride lipase and hormone-sensitive lipase production for lipolysis and increases phosphorylation of AMP-activated protein kinase (AMPK), resulting in decreased activity of acetyl-CoA carboxylase for fatty acid synthesis^[1].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	The 3T3-L1 murine preadipocyte cell line
	濃度
	反応時間	24 h
	実験の流れ	3T3-L1 cells are treated with various concentrations of ginkgolide C in 96-well plates for 24 h. Cell viability is analyzed by the MTT assay. The culture medium is removed, and the cells are incubated with 100 μL MTT solution (5 mg/mL) for 4 h at 37°C. After plates are washed, isopropanol is added to dissolve formazone crystals, followed by absorbance detection with a spectrophotometer at 570 nm.
動物実験	動物モデル	Male ddY mice
	投薬量	1 mg/kg
	投与方法	oral administration

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

MK8722, an AMPK activator, inhibiting carcinoma proliferation, invasion and migration in human pancreatic cancer cells [ Biomed Pharmacother, 2021, 144:112325]	PubMed: 34656065

MK8722, an AMPK activator, inhibiting carcinoma proliferation, invasion and migration in human pancreatic cancer cells [ Biomed Pharmacother, 2021, 144:112325]

PubMed: 34656065

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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