Glucosamine hydrochloride

製品コードS3694 バッチS369401

化学情報

	Synonyms	2-Amino-2-deoxy-glucose HCl, Chitosamine HCl	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₆H₁₃NO₅.HCl
	分子量	215.63	CAS No.	66-84-2
Solubility (25°C)*	体外	Water	43 mg/mL (199.41 mM)
		DMSO	4 mg/mL (18.55 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
in vitro	Glucosamine enters the hexosamine biosynthetic pathway (HBP) downstream of the rate-limiting step catalyzed by the GFAT (glutamine:fluctose-6-phosphate amidotransferase), providing UDP-GlcNAc substrates for O-linked β-N-acetylglucosamine (O-GlcNAc) protein modification. Glucosamine inhibits proteasomal activity and the proliferation of ALVA41 prostate cancer cells. The inhibition of proteasomal activity results in the accumulation of ubiquitinated proteins, followed by induction of apoptosis. Glucosamine downregulates proteasome activator PA28γ and overexpression of PA28γ rescues the proteasomal activity and growth inhibition mediated by glucosamine^[1]. Glucosamine inhibits the proliferation of RCC cells by promoting cell cycle arrest at G0/G1 phase, but not promoting apoptosis^[2].
in vivo	Glucosamine could significantly inhibit the production of nitric oxide and prostagladin E2 and suppress the progression of adjuvant arthritis in rats. Glucosamine may be expected as a novel anti-inflammatory agent for treatment of rheumatoid arthritis. Administration of glucosamine normalizes cartilage metabolism, so as to inhibit the degradation and stimulate the synthesis of proteoglycans, and to restore the articular function. Glucosamine has been demonstrated to prolong the allogeneic cardiac allograft survival by repressing the activation of T-lymphoblasts and dendritic cells^[3].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	ALVA41 cells
	濃度	0-2 mM
	反応時間	24 h
	実験の流れ	ALVA41 cells are treated with various concentrations of glucosamine (GlcN) for 24 h, and cell viability is analyzed using MTT assay.
動物実験	動物モデル	Male Wistar rats
	投薬量	300 mg/kg
	投与方法	oral

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism. [ EBioMedicine, 2019, 39:540-551]	PubMed: 30578080

Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism. [ EBioMedicine, 2019, 39:540-551]

PubMed: 30578080

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。