GSH (Glutathione)

製品コードS4606 バッチS460603

印刷

化学情報

Chemical Structure Synonyms Isethion, Glutathion, Tathion, L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine Storage
(From the date of receipt)		 3 years -20°C(in the dark) powder
化学式

C10H17N3O6S
分子量 307.32 CAS No. 70-18-8
Solubility (25°C)* 体外 Water 46 mg/mL (149.68 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 GSH (Glutathione) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.
in vitro

Glutathione (GSH) is able to recover the meiotic failure induced by heavy metal cadmium (Cd) exposure through suppressing the excessive ROS level, DNA damage accumulation and apoptotic incidence in porcine oocytes.[2]
in vivo

Oral GSH can increase GSH concentrations in several tissues following GSH depletion.[1]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 porcine oocytes
濃度 1, 2 and 4 mM
反応時間 --
実験の流れ

Cadmium chloride is dissolved in PBS and diluted in TCM-199 medium to a final concentration of 0.4, 2, 10 and 50 μM, respectively. GSH is dissolved in PBS and diluted in TCM-199 medium to a final concentration of 1, 2 and 4 mM, respectively. Both cadmium chloride and GSH are supplemented to TCM-199 medium immediately before culture.
動物実験 動物モデル Mice (outbred albino ICR, 30-40 g)
投薬量 100 mg/kg
投与方法 oral administration

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade [ Nat Commun, 2023, 14(1):4758] PubMed: 37553341
Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade [ Nat Commun, 2023, 14(1):4758] PubMed: 37553341
Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8+-T cell immunity [ J Exp Clin Cancer Res, 2023, 42(1):118] PubMed: 37161450
Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria [ Cell Rep, 2023, 42(9):113147] PubMed: 37756158
Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote glioblastoma cell ferroptosis [ Cancer Cell Int, 2023, 23(1):5] PubMed: 36639654
Glutathione promotes the synergistic effects of venetoclax and azacytidine against myelodysplastic syndrome‑refractory anemia by regulating the cell cycle [ Exp Ther Med, 2023, 26(6):574] PubMed: 38023359
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis [ Cell Stem Cell, 2022, 29(7):1119-1134.e7] PubMed: 35803229
Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models [ Nat Commun, 2022, 13(1):7335] PubMed: 36443325
Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response [ Environ Int, 2022, 158:106989] PubMed: 34991250
HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis [ Cell Death Dis, 2022, 13(10):861] PubMed: 36209275

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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