受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
|
化学式 | C17H14F2N2 |
|||
分子量 | 284.3 | CAS No. | 1139889-93-2 | |
Solubility (25°C)* | 体外 | DMSO | 57 mg/mL (200.49 mM) | |
Ethanol | 4 mg/mL (14.06 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Golgicide A is a potent and rapidly reversible GBF1 inhibitor. |
---|---|
in vitro | Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM. Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport. [1] Golgicide A decreases HCV RNA levels in FLRP1 cells and J6/JFH1 cells. In addition, Golgicide A causes redistribution of NS5A and accumulation of infectious viral particles in J6/JFH1 cells. [2] |
|
Data from [Data independently produced by , , J Biosci, 2017, 42(1):43-56]
STING1 is essential for an RNA-virus triggered autophagy [ Autophagy, 2021, 1-13] | PubMed: 34338134 |
The Regulatory Role of GBF1 on Osteoclast Activation Through EIF2a Mediated ER Stress and Novel Marker FAM129A Induction [ Front Cell Dev Biol, 2021, 9:706768] | PubMed: 34513838 |
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway [Gui X, et al Nature, 2019, 567(7747):262-266] | PubMed: 30842662 |
Niclosamide Triggers Non-Canonical LC3 Lipidation [ Cells, 2019, 8(3)] | PubMed: 30875964 |
Regulatory role of Golgi brefeldin A resistance factor-1 in amyloid precursor protein trafficking, cleavage and Aβ formation. [ J Cell Biochem, 2019, 120(9):15604-15615] | PubMed: 31111546 |
Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression [Yan H J Nat Med, 2019, 10.1007/s11418-019-01287-7] | PubMed: 30758716 |
Intracellular trafficking of begomoviruses in the midgut cells of their insect vector [ PLoS Pathog, 2018, 14(1):e1006866] | PubMed: 29370296 |
CSFV proliferation is associated with GBF1 and Rab2 [Liang W J Biosci, 2017, 42(1):43-56] | PubMed: 28229964 |
Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy [ Cell Death Dis, 2016, 7(8):e2330] | PubMed: 27512951 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。