受注:045-509-1970 |
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Synonyms | Gossypol Acetic acid, Pogosin, AT101 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C32H34O10 |
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分子量 | 578.61 | CAS No. | 12542-36-8 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (172.82 mM) | |
Ethanol | 10 mg/mL (17.28 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Gossypol Acetate (Gossypol Acetic acid, Pogosin, AT101) is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes. |
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in vitro | Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner[1]. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro[2]. |
in vivo | Gossypol acetate is able to inhibit tumor growth in Wus1-bearing mice, but the survival of mice is not prolonged, and tumor grows rapidly after short inhibition. Gossypol has now been found to have inhibitory effects on proliferation or to induce apoptosis in ovarian cancer, endometrial cancer, adrenal cortical tumor, thyroid cancer, lung cancer, colon carcinoma, leukemia, pancreatic cancer, melanoma and lymphoma. In addition, gossypol can increase the sensitivity of drug-resistant tumor cells to chemotherapy and radiotherapy. Some clinical trials showed gossypol is well-tolerated, and partial responses are observed in some patients[4]. |
細胞アッセイ | 細胞株 | Human MM cell lines U266 and Wus1 |
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濃度 | 1, 5, 10, 25 and 50 µmol/l | |
反応時間 | 0, 24, 48 and 72 h | |
実験の流れ | MM(Multiple myeloma) cells are plated in 24-cell culture clusters at a density of 1x105 viable cells/l per well. Triplicate wells are treated with 1, 5, 10, 25 and 50 µmol/l gossypol acetate, and the negative control group is supplemented with 0.1% DMSO. Then, cell numbers at different treatment time points (0, 24, 48 and 72 h) are determined by using a hemocytometer and the trypan blue dye-exclusion method. The trypan blue dye-exclusion method is used to evaluate the cell viability. The cells are examined in a counting chamber under a light microscope. Only viable cells are recorded. |
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動物実験 | 動物モデル | sexually mature adult male Wistar rats |
投薬量 | 10 and 25 mg/kg | |
投与方法 | oral administration |
Data from [Data independently produced by Georg August University Gottingen, 2014, Western blotting]
, , Pest Manag Sci, 2016, 73(8):1670-1678
Data from [Data independently produced by , , Mol Nutr Food Res, 2017, 61(4)]
TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS [ J Mol Cell Biol, 2023, 15(3)mjad017] | PubMed: 36921991 |
Identification of Gossypol Acetate as an Autophagy Modulator with Potent Anti-tumor Effect against Cancer Cells [ J Agric Food Chem, 2022, 70(8):2589-2599] | PubMed: 35180345 |
Gossypol Treatment Restores Insufficient Apoptotic Function of DFF40/CAD in Human Glioblastoma Cells [ Cancers (Basel), 2021, 13(21)5579] | PubMed: 34771741 |
Divergent and Overlapping Roles for Selected Phytochemicals in the Regulation of Pathological Cardiac Hypertrophy [ Molecules, 2021, 26(5)1210] | PubMed: 33668293 |
Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression [ Mol Med Rep, 2021, 23(1)40] | PubMed: 33179075 |
Effect of Exosomal APE1 on Sensitivity of NSCLC A549 Cells to Cisplatin [ Cancer Research on Prevention and Treatment, 2020, 47(7): 492-497] | PubMed: None |
Gossypol overcomes EGFR-TKIs resistance in non-small cell lung cancer cells by targeting YAP/TAZ and EGFRL858R/T790M [ Biomed Pharmacother, 2019, 115:108860] | PubMed: 31055235 |
Dual effects of gossypol on human hepatocellular carcinoma via endoplasmic reticulum stress and autophagy [ Int J Biochem Cell Biol, 2019, 113:48-57] | PubMed: 31128260 |
Gossypol Inhibits Non-small Cell Lung Cancer Cells Proliferation by Targeting EGFRL858R/T790M [Wang Y Front Pharmacol, 2018, 9:728] | PubMed: 30038571 |
Effect of the BH3 Mimetic Polyphenol (-)-Gossypol (AT-101) on the in vitro and in vivo Growth of Malignant Mesothelioma [Benvenuto M Front Pharmacol, 2018, 9:1269] | PubMed: 30459622 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。