受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
||||||||
化学式 | C14H22Cl2N2 |
||||||||||
分子量 | 289.24 | CAS No. | 2102933-95-7 | ||||||||
Solubility (25°C)* | 体外 | DMSO (warmed with 50ºC water bath) | 57 mg/mL (197.06 mM) | ||||||||
Water (warmed with 50ºC water bath) | 57 mg/mL (197.06 mM) | ||||||||||
体内 (毎回新しく調製した物を用意してください) |
|
||||||||||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). |
---|---|
in vitro | GSK-LSD1 induces gene expression changes in cancer cell lines with average EC50 of < 5 nM and inhibits cancer cell line growth with average EC50 of < 5 nM. [1] |
in vivo | GSK-LSD1, a highly selective inhibitor of KDM1A, significantly inhibits thyroid cancer progression and enhances the sensitivity of thyroid cancer to chemotherapy. |
細胞アッセイ | 細胞株 | U2OS cells |
---|---|---|
濃度 | 200 μM | |
反応時間 | 12 h | |
実験の流れ | Cells were treated with indicated concentration of drug for 12 h. |
|
動物実験 | 動物モデル | Nude mice |
投薬量 | 1 mg/kg | |
投与方法 | i.p. |
|
Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced anti-tumor effects with ferroptosis inducers in NSCLC [ Cell Death Dis, 2023, 10.1038/s41419-023-06238-5] | PubMed: 37923740 |
Insect immunity and its interactions with microorganisms and parasitoids [ Front Immunol, 2023, ] | PubMed: none |
Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation [ Cell Death Differ, 2022, 10.1038/s41418-022-00983-4] | PubMed: 35379950 |
KDM1A promotes thyroid cancer progression and maintains stemness through the Wnt/β-catenin signaling pathway [ Theranostics, 2022, 12(4):1500-1517] | PubMed: 35198054 |
BmCPV-Derived Circular DNA vcDNA-S7 Mediated by Bombyx mori Reverse Transcriptase (RT) Regulates BmCPV Infection [ Front Immunol, 2022, 13:861007] | PubMed: 35371040 |
BmCPV-Derived Circular DNA vcDNA-S7 Mediated by Bombyx mori Reverse Transcriptase (RT) Regulates BmCPV Infection [ Front Immunol, 2022, 13:861007] | PubMed: 35371040 |
Lysine specific demethylase 1 inhibitor alleviated lipopolysaccharide/D-galactosamine-induced acute liver injury [ Eur J Pharmacol, 2022, 932:175227] | PubMed: 36007605 |
ZKSCAN5 Activates VEGFC Expression by Recruiting SETD7 to Promote the Lymphangiogenesis, Tumour Growth, and Metastasis of Breast Cancer [ Front Oncol, 2022, 12:875033] | PubMed: 35600335 |
PDI inhibitor LTI6426 enhances panobinostat efficacy in preclinical models of multiple myeloma [ Cancer Chemother Pharmacol, 2022, 89(5):643-653] | PubMed: 35381875 |
Eupalinilide B as a novel anti-cancer agent that inhibits proliferation and epithelial-mesenchymal transition in laryngeal cancer cells [ J Int Med Res, 2022, 50(1):3000605211067921] | PubMed: 35098772 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。