Homatropine Bromide

製品コードS4025 バッチS402501

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C16H21NO3.HBr
分子量 356.25 CAS No. 51-56-9
Solubility (25°C)* 体外 DMSO 71 mg/mL (199.29 mM)
Water 71 mg/mL (199.29 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
in vitro Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. [2] Homatropine has similar affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses. [3]
in vivo Homatropine (20 mg/kg) prevents lethality in rats with dichlorvos poisoning with survive rate of 30% and time of death ranged between 4 and 12 minutes, while Homatropine (10 mg/kg) has no effect on preventing lethality. [4] Homatropine [14C]methylbromide administrated rectal achieves higher and rapid peak plasma concentrations than by the other routes in rats whether HMB-14C is administered in a water-soluble suppository base or in aqueous solution, retained 28% of the 14C has been excreted in the urine while 56% remained in the large intestine after 12 hours. Unlabelled Homatropine methylbromide, given in rectal suppositories to anaesthetized rats, causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure. [5]

プロトコル(参考用のみ)

キナーゼアッセイ Binding assay
The binding assays are terminated by centrifugation (15 min at 3.6 x 105 g for endothelial and 5 x 104 g for smooth muscle membranes). The pellets obtained are rinsed rapidly three times with 0.6 mL ice-cold modified Krebs buffer. The tubes are then air dried and the pellets resuspended in scintillation cocktail and counted in a scintillation counter with a counting efficiency of 60%.
動物実験 動物モデル Sprague-Dawley rats
投薬量 20 mg/kg
投与方法 Intramuscular (IM) injections

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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