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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | ||||
化学式 | C20H13N5 |
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分子量 | 323.35 | CAS No. | 150651-39-1 | ||||
Solubility (25°C)* | 体外 | DMSO | 20 mg/mL (61.85 mM) | ||||
Water | Insoluble | ||||||
Ethanol | Insoluble | ||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1/AIFM2) with EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout Pfa1 and HT1080 cells that overexpresses FSP1.Solutions are unstable and should be fresh-prepared. |
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in vitro | iFSP1 selectively induces ferroptosis in GPX4-knockout Pfa1 and HT1080 cells that overexpressed FSP1. FSP1 is expressed in most tumour cell lines, and iFSP1 treatment robustly sensitizes these cells to RSL3-induced ferroptosis.[1] |
細胞アッセイ | 細胞株 | human cancer cell lines (NCl-H1437, U-373, MDA-MB-436, SW620, MDA-MB-435S, A549, etc.) |
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濃度 | 0.01 μM - 10 μM, 3 μM | |
反応時間 | 24 h | |
実験の流れ | Cells are seeded on 96-well plates (2,500 cells per well) and treated with iFSP-1 after plating. Cell viability is assessed 24 h (unless stated otherwise) after treatment using AquaBluer as an indicator of viable cells according to the manufacturer's recommendations. |
Phospholipase PLA2G7 is complementary to GPX4 in mitigating punicic-acid-induced ferroptosis in prostate cancer cells [ iScience, 2024, 27(5):109774] | PubMed: 38711443 |
Astragaloside IV ameliorates cisplatin-induced liver injury by modulating ferroptosis-dependent pathways [ J Ethnopharmacol, 2024, 328:118080] | PubMed: 38521426 |
Suppression of ferroptosis by vitamin A or antioxidants is essential for neuronal development [ bioRxiv, 2023, 10.1101/2023.04.05.535746] | PubMed: None |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。