Iopromide

製品コードS3207 バッチS320701

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₈H₂₄I₃N₃O₈
	分子量	791.11	CAS No.	73334-07-3
Solubility (25°C)*	体外	DMSO	100 mg/mL (126.4 mM)
		Water	100 mg/mL (126.4 mM)
		Ethanol	100 mg/mL (126.4 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the path of flow of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs.
in vitro	No toxic effects are detected at the highest tested concentration of Iopromide (10 g/L) in short-term toxicity tests with bacteria (Vibrio fisheri, Pseudomonas putida), algae (Scenedesmus subspicatus), crustaceans (Daphnia magna), and fish (Danio rerio, Leuciscus idus). Iopromide results in the ratio between the predicted environmental concentration (PEC) and the predicted no-effect concentration (PNEC) of 2 × 10^-4 using an assessment factor of 100. ^[1] Iopromide results in the photocatalytic degradation values k of 0.18 and the coefficient of determination R² of 0.997 in Milli-Q water with suspended TiO₂. ^[2] The percent removal of Iopromide decreases from 97% to 86% when the activity of the nitrifying bacteria is inhibited. Iopromide results in metabolite of carboxylate formed during the oxidation of the primary alcohol on the side chain of iopromide when the nitrifying bacteria are inhibited. ^[3] Iopromide (0.1 mg/L to 0.27 mg/L) is removed more effectively in the nitrifying activate sludge which has a higher SRT (49 days) than in the conventional activated sludge (SRT of 6 days). Iopromide (0.1 mg/L to 0.27 mg/L) is removed more effectively in the nitrifying activate sludge which has a higher SRT (49 days) than in the conventional activated sludge (SRT of 6 days). The percent removal of Iopromide in the wastewater treatment plants reaches 61% in nitrifying activated sludge. ^[4] Iopromide-dosed plant at 0.1 mg/L, 1 mg/L and 100 mg/L results in the median of DOC-degradation of the synthetic sewage of 88.5%, 90.5%, 88.4% and 85.1%, respectively. Iopromide is eliminated to more than 80% in the 100 mg/L concentration after a lag period of 31 days. In the LSTP incubated with 1 mg/L Iopromide elimination reaches more than 80% after 38 days. Iopromide results in half-life of photodegradation of free amine of 4.21 hours. ^[5]

製品説明

Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the path of flow of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs.

in vitro

No toxic effects are detected at the highest tested concentration of Iopromide (10 g/L) in short-term toxicity tests with bacteria (Vibrio fisheri, Pseudomonas putida), algae (Scenedesmus subspicatus), crustaceans (Daphnia magna), and fish (Danio rerio, Leuciscus idus). Iopromide results in the ratio between the predicted environmental concentration (PEC) and the predicted no-effect concentration (PNEC) of 2 × 10^-4 using an assessment factor of 100. ^[1] Iopromide results in the photocatalytic degradation values k of 0.18 and the coefficient of determination R² of 0.997 in Milli-Q water with suspended TiO₂. ^[2] The percent removal of Iopromide decreases from 97% to 86% when the activity of the nitrifying bacteria is inhibited. Iopromide results in metabolite of carboxylate formed during the oxidation of the primary alcohol on the side chain of iopromide when the nitrifying bacteria are inhibited. ^[3] Iopromide (0.1 mg/L to 0.27 mg/L) is removed more effectively in the nitrifying activate sludge which has a higher SRT (49 days) than in the conventional activated sludge (SRT of 6 days). Iopromide (0.1 mg/L to 0.27 mg/L) is removed more effectively in the nitrifying activate sludge which has a higher SRT (49 days) than in the conventional activated sludge (SRT of 6 days). The percent removal of Iopromide in the wastewater treatment plants reaches 61% in nitrifying activated sludge. ^[4] Iopromide-dosed plant at 0.1 mg/L, 1 mg/L and 100 mg/L results in the median of DOC-degradation of the synthetic sewage of 88.5%, 90.5%, 88.4% and 85.1%, respectively. Iopromide is eliminated to more than 80% in the 100 mg/L concentration after a lag period of 31 days. In the LSTP incubated with 1 mg/L Iopromide elimination reaches more than 80% after 38 days. Iopromide results in half-life of photodegradation of free amine of 4.21 hours. ^[5]

プロトコル(参考用のみ)

参考

+ 展开

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. [ Nat Commun, 2019, 10(1):2130]	PubMed: 31086178

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. [ Nat Commun, 2019, 10(1):2130]

PubMed: 31086178

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。