IQ-1

製品コードS8248 バッチS824801

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₁H₂₂N₄O₂
	分子量	362.42	CAS No.	331001-62-8
Solubility (25°C)*	体外	DMSO	72 mg/mL (198.66 mM)
		Ethanol	7 mg/mL (19.31 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.
in vivo	IQ1 decreases the size of the lung and dramatically decreased the number of branching tips. Despite the branching inhibition at the distal tips, IQ1 causes an elongation of the proximal airway compared to the control lung at E14.5. This elongation of the proximal airways suggests that the impact of IQ1 is not due simply to growth inhibition. IQ1 also inhibits branching with 3 day treatment initiating at E9.9; IQ1 causes airway dilation and decreased the density of mesenchymal cells. IQ1 also affects cardiac and vascular system development. IQ1 decreases the expression of distal genes and increased the expression of proximal genes in the lung explants consistent with the hypothesis that inhibition of the β-catenin/p300 interaction proximalizes lung epithelium^[2].

製品説明

IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.

in vivo

IQ1 decreases the size of the lung and dramatically decreased the number of branching tips. Despite the branching inhibition at the distal tips, IQ1 causes an elongation of the proximal airway compared to the control lung at E14.5. This elongation of the proximal airways suggests that the impact of IQ1 is not due simply to growth inhibition. IQ1 also inhibits branching with 3 day treatment initiating at E9.9; IQ1 causes airway dilation and decreased the density of mesenchymal cells. IQ1 also affects cardiac and vascular system development. IQ1 decreases the expression of distal genes and increased the expression of proximal genes in the lung explants consistent with the hypothesis that inhibition of the β-catenin/p300 interaction proximalizes lung epithelium^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Rat EMCs, an epicardial mesothelial cell line
	濃度	10 μM
	反応時間	24 h
	実験の流れ
動物実験	動物モデル	TOPGAL mice(timed pregnant mice)
	投薬量	72 or 144 mg/kg/day
	投与方法	oral administration

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Osteoprogenitor SFRP1 prevents exhaustion of hematopoietic stem cells via PP2A-PR72/130-mediated regulation of p300 [ Haematologica, 2022, 10.3324/haematol.2022.280760]	PubMed: 35950533
CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2 [ Neoplasia, 2020, 23(1):1-11]	PubMed: 33190089
A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development. [ Cell Mol Life Sci, 2019, 76(14):2817-2832]	PubMed: 30887098
A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis [ Front Genet, 2018, 9:746]	PubMed: 30728831

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。