受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | endo-IWR 1, IWR-1 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
|
化学式 | C25H19N3O3 |
|||
分子量 | 409.44 | CAS No. | 1127442-82-3 | |
Solubility (25°C)* | 体外 | DMSO | 41 mg/mL (100.13 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | IWR-1-endo (endo-IWR 1, IWR-1) is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
---|---|
in vitro | Although both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. [1] |
in vivo | IWR-1 is a β‐catenin inhibitor.[3] |
細胞アッセイ | 細胞株 | Pig EpiSCs |
---|---|---|
濃度 | 2.5 μM | |
反応時間 | 2 days | |
実験の流れ | For neural induction, the 3i/LAF culture medium was replaced with neural induction medium I (2.5 μM IWR-1-endo, 5 μM SB431542, and 10 ng/mL FGF2 in BM) on day 2 after pgEpiSC passage. |
|
動物実験 | 動物モデル | BALB/c nude mice |
投薬量 | 160 μg/kg | |
投与方法 |
|
Data from [Data independently produced by , , Diabetes, 2018, 67(4):554-568]
Data from [Data independently produced by , , Biochim Biophys Acta Mol Cell Biol Lipids, 2018, 1863(8):834-843]
Data from [Data independently produced by , , Am J Cancer Res, 2015, 5(10):3123-3134.]
Derivation of human primordial germ cell-like cells in an embryonic-like culture [ Nat Commun, 2024, 15(1):167] | PubMed: 38167821 |
Autophagy is essential for human myelopoiesis [ Stem Cell Reports, 2024, 19(2):196-210] | PubMed: 38215759 |
Inhibitor of Wnt receptor 1 suppresses the effects of Wnt1, Wnt3a and β‑catenin on the proliferation and migration of C6 GSCs induced by low‑dose radiation [ Oncol Rep, 2024, 51(2)22] | PubMed: 38099414 |
CXXC finger protein 1 -CFP1) bridges the reshaping of genomic H3K4me3 signature to the advancement of lung adenocarcinoma [ Signal Transduct Target Ther, 2023, 8(1):369] | PubMed: 37735441 |
CXXC finger protein 1 (CFP1) bridges the reshaping of genomic H3K4me3 signature to the advancement of lung adenocarcinoma [ Signal Transduct Target Ther, 2023, 8(1):369] | PubMed: 37735441 |
A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems [ Cell Discov, 2023, 9(1):53] | PubMed: 37280224 |
Direct 3D-Bioprinting of hiPSC-Derived Cardiomyocytes to Generate Functional Cardiac Tissues [ Adv Mater, 2023, 35(52):e2305911] | PubMed: 37655652 |
Long-term in vivo chimeric cells tracking in non-human primate [ Protein Cell, 2023, pwad049] | PubMed: 37758041 |
Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos [ Natl Sci Rev, 2023, 10(9):nwad173] | PubMed: 37593113 |
Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos [ Natl Sci Rev, 2023, 10(9):nwad173] | PubMed: 37593113 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。