Ixazomib Citrate (MLN9708)

製品コードS4432 バッチS443201

化学情報

	Synonyms		Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₂₀H₂₃BCl₂N₂O₉
	分子量	517.12	CAS No.	1239908-20-3
Solubility (25°C)*	体外	DMSO	100 mg/mL (193.37 mM)
		Ethanol	100 mg/mL (193.37 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Ixazomib Citrate (MLN9708) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.

プロトコル(参考用のみ)

参考

[4] Ruzena Vlasakova, et al. WO2016165677A1.

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors [ J Exp Clin Cancer Res, 2022, 41(1):249]	PubMed: 35971164
NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma [ Cell Death Dis, 2022, 13(3):197]	PubMed: 35236820
Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation [ Front Pharmacol, 2022, 13:1032975]	PubMed: 36313330
Proteasome Inhibition Overcomes ALK-TKI Resistance in ALK-Rearranged/TP53-Mutant NSCLC via Noxa Expression [ Clin Cancer Res, 2021, 27(5):1410-1420]	PubMed: 33310890
Hybrid sequencing-based personal full-length transcriptomic analysis implicates proteostatic stress in metastatic ovarian cancer [ Oncogene, 2019, 38(16):3047-3060]	PubMed: 30617306
The Zinc-Finger AN1-Type Domain 2a Gene Acts as a Regulator of Cell Survival in Human Melanoma: Role of E3-Ligase cIAP2 [ Mol Cancer Res, 2019, 17(12):2444-2456]	PubMed: 31540997
Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers [ Proc Natl Acad Sci U S A, 2017, 114(2):382-387]	PubMed: 28028240
The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma [ Mol Cancer Ther, 2017, 16(11):2375-2386]	PubMed: 28878026
Identification of the anticancer effects of a novel proteasome inhibitor, ixazomib, on colorectal cancer using a combined method of microarray and bioinformatics analysis [ Onco Targets Ther, 2017, 10:3591-3606]	PubMed: 28790851
Ixazomib enhances parathyroid hormone-induced β-catenin/T-cell factor signaling by dissociating β-catenin from the parathyroid hormone receptor [ Mol Biol Cell, 2017, 28(13):1792-1803]	PubMed: 28495797

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。