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Synonyms | Monosodium glutamate, MSG | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C5H8NO4.Na |
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分子量 | 169.11 | CAS No. | 142-47-2 | |
Solubility (25°C)* | 体外 | Water | 33 mg/mL (195.13 mM) | |
DMSO | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | L-Glutamic acid monosodium salt (Monosodium glutamate, MSG) is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. |
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in vitro | Monosodium glutamate(MSG) induces apoptosis in human B cells. It has a more potent apoptotic effect in naïve B cells compared to memory B cell population[3]. Low doses of L-monosodium glutamate promote neuronal growth and differentiation in vitro[4]. |
in vivo | Daily monosodium glutamate(MSG) dietary consumption reduces pancreatic β-cell mass and enhances hemorrhages and fibrosis, but does not affect glucose homeostasis. High dietary MSG intake may exert a negative effect on the pancreas and such effect might become functionally significant in the presence or susceptibility to diabetes or NaCl. Parenteral MSG causes various changes in pancreatic islets such as hypertrophy, hyperplasia, decrease in acinar cells, α-cells and somatostatin cells and increase in fibrosis[1]. MSG may have some deleterious effects on the testes of Wistar rats and by extension may contribute to the causes of male infertility[2]. |
細胞アッセイ | 細胞株 | human B cells |
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濃度 | 1-100 mM | |
反応時間 | 24 h | |
実験の流れ | B cells are cultured with and with out increasing concentrations of MSG(1-100 mM) for 24 h. The number of early apoptotic cells and necrotic cells is determined using Annexin-V FITC/PI staining. | |
動物実験 | 動物モデル | Adult male Wistar rats |
投薬量 | 2 mg/g | |
投与方法 | Oral administration |
SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus [ Heliyon, 2024, 10(1):e23945] | PubMed: 38205297 |
Soft substrates promote direct chemical reprogramming of fibroblasts into neurons [ Acta Biomater, 2022, 152:255-272] | PubMed: 36041647 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。