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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C30H40N4O6S |
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分子量 | 584.73 | CAS No. | 159182-43-1 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (171.01 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types. |
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in vitro | L-755,507 displays an excellent activity profile as an extremely potent human β3 adrenergic receptor agonist (β3 EC50 0.43 nM), with >440-fold selectivity over β1 and β2 binding[1]. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors(pEC50 values of 12.3)[4]. In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold[3]. |
in vivo | Acute exposure of rhesus monkeys to L-755,507 elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue[2]. |
細胞アッセイ | 細胞株 | cancer cell lines(K562 and HeLa), suspension cells (K562), primary neonatal cells (HUVEC and fibroblast CRL-2097), and human ESC derived cells (neural stem cells) |
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濃度 | 5 μM | |
反応時間 | 24 hours | |
実験の流れ | -- |
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動物実験 | 動物モデル | Male lean rhesus monkeys |
投薬量 | 3 mg/kg | |
投与方法 | i.v. |
In situ correction of various β-thalassemia mutations in human hematopoietic stem cells [ Front Cell Dev Biol, 2023, 11:1276890] | PubMed: 38333188 |
Identifying key underlying regulatory networks and predicting targets of orphan C/D box SNORD116 snoRNAs in Prader-Willi syndrome [ bioRxiv, 2023, 10.1101/2023.10.03.560773] | PubMed: 37873184 |
An effective double gene knock-in strategy using small-molecule L755507 in the medaka fish (Oryzias latipes) [ Genesis, 2022, 60(1-2):e23465] | PubMed: 35072325 |
Construction of Synthetic Nanobody Library in Mammalian Cells by dsDNA-Based Strategies* [ Chembiochem, 2021, 22(20):2957-2965] | PubMed: 34411391 |
Functional Interrogation of Lynch Syndrome Associated MSH2 Missense Variants via CRISPR-Cas9 Gene Editing in Human Embryonic Stem Cells [ Hum Mutat, 2019, 10.1002/humu.23848] | PubMed: 31237724 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。