Lauric Acid

製品コードS4726 バッチS472601

化学情報

	Synonyms	dodecanoic acid, N-Dodecanoic acid, Dodecylic acid	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₂H₂₄O₂
	分子量	200.32	CAS No.	143-07-7
Solubility (25°C)*	体外	DMSO	40 mg/mL (199.68 mM)
		Ethanol	40 mg/mL (199.68 mM)
		Water	20 mg/mL (99.84 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid) is a saturated medium-chain fatty acid with a 12-carbon backbone. Lauric acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
in vitro	Lauric acid induces apoptosis in Caco-2 (p<0.05) and IEC-6 cells (p<0.05). In Caco-2 cells, lauric acid reduces GSH availability and generated ROS compared to butyrate(p < 0.05). Lauric acid reduces Caco-2 and IEC-6 cells in G0/G1 and arrested cells in the S and G2/M phases. Lauric acid induces apoptosis in IEC-6 cells compared to butyrate(p < 0.05). Lauric acid induces high levels of ROS^[1].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Caco-2 and IEC-6 cell lines
	濃度	0.1, 0.3, 0.5 and 1 mM
	反応時間	24, 48, 72, and 96 h
	実験の流れ	Cell lines are harvested by enzymatic dissociation and seeded into 24-well tissue culture plates at 2.5 × 10⁵ and 1.5 × 10⁵ cells/ml, respectively. After 24 h of incubation, the medium is replaced with 1 ml of complete DMEM containing freshly prepared (50 mM )Lauric acid, conjugated to 0.4% FAF-BSA to final concentrations of 0.1, 0.3, 0.5 and 1 mM and compared to NaB (5 mM ) with 50 μl of 0.4% FAF-BSA as a vehicle control and incubated in a humidified atmosphere at 37℃ in 5% CO₂ and, after enzymatic dissociation, assayed at 24, 48, 72, and 96 h. All experimental studies are undertaken in triplicate and measured in duplicate.

参考

[1] Fauser JK, et al. Chemotherapy. 2013, 59(3):214-24.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation [ Nat Commun, 2023, 14(1):660]	PubMed: 36750575

Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation [ Nat Commun, 2023, 14(1):660]

PubMed: 36750575

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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