Liquiritin

製品コードS3930 バッチS393001

印刷

化学情報

Chemical Structure Synonyms Liquiritoside, Liquiritigenin-4'-O-glucoside Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C21H22O9
分子量 418.39 CAS No. 551-15-5
Solubility (25°C)* 体外 DMSO 100 mg/mL (239.01 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Liquiritin (LIQ, Liquiritoside, Liquiritigenin-4'-O-glucoside) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.
in vitro Liquiritin exerts neuroprotective and neurotrophic effects on primary cultured hippocampal cells[1]. Liquiritin may enhance cell survival by increasing the protein expression level of glucose-6 phosphate dehydrogenase. Liquiritin potentiates neurite outgrowth induced by nerve growth factor in PC12 cells. It affects particular types of cells such as neurons in the central nervous system. Liquiritin increases the proliferation of B65 neuroblastoma cells[2].
in vivo Liquiritin at doses of 50-100 mg/kg significantly improves the cognitive ability, restores the abnormal activities of glutathione peroxidase and superoxide dismutase, and decreases the levels of malondialdehyde，8-hydroxy-2′-deoxyguanosine and protein carbonyl in the hippocampus of rats with Alzheimer's disease. Liquiritin can significantly ameliorate Aβ1-42-induced spatial learning and memory impairment by inhibiting oxidative stress and neural apoptosis. It is also frequently used to treat injury or swelling owing to its life-enhancing properties, as well as detoxification in traditional oriental medicine. It exerts significant antidepressant-like effects on the forced swimming and tail suspension tests in mice. It can also produce obvious neuroprotective effects on focal cerebral ischemia/reperfusion induced by middle cerebral artery occlusion. Liquiritin can protect neurons from Aβ-induced neurotoxicity. This ability probably involves the suppression of oxidative stress and neuron apoptosis in a rat model of Alzheimer disease (AD) induced by subsequent bilateral intrahippocampal (IH) injections of aggregated soluble oligomeric Aβ1-42. Liquiritin provides beneficial effects on the cognitive impairments observed in an Aβ1-42-induced model of AD. The neuroprotective effects of liquiritin are closely associated with its effects of inhibiting oxidative stress and neuronal apoptosis[1].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 B65 neuroblastoma cells
濃度 --
反応時間 24, 48 and 72 h
実験の流れ The proliferation of B65 neuroblastoma cells was investigated by a WST-8 assay using a Cell Counting Kit-8. Once cells became confluent, they were plated into 96-well microplates at a density of 5×104/mL (5×103/well) and incubated with glycyrrhizin, isoliquiritin and liquiritin, which were first dissolved in dimethyl sulfoxide (DMSO). When cells were treated with these compounds, the final concentration of DMSO was set at 0.1% in the culture medium. When cells were treated with various cytotoxic reagents, such as hydrogen peroxide, monosodium glutamate, or menadione sodium bisulfate, these agents were directly dissolved in culture media following the description in each experiment. In general, this assay was performed after cells were cultured with each compound or reagent for 24, 48 and 72 h. After culture, the cells were incubated with WST-8 solution at 37℃ for 2 h, and the spectrophotometric absorbance of WST-8-formazan produced by dehydrogenase activity in the living cells at 450 nm.
動物実験 動物モデル Adult male Sprague-Dawley rats
投薬量 100, 50, or 25 mg/kg
投与方法 orally administered

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。