受注:045-509-1970 |
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Synonyms | Luteoline, Luteolol, Digitoflavone | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C15H10O6 |
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分子量 | 286.24 | CAS No. | 491-70-3 | |
Solubility (25°C)* | 体外 | DMSO | 57 mg/mL (199.13 mM) | |
Ethanol | 3 mg/mL warmed with 50ºC water bath (10.48 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. |
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in vitro | Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. [1] Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha. [2] |
in vivo | LD50: Mice >2500mg/kg (i.g.) [3] |
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, , Mol Nutr Food Res, 2017, doi: 10.1002/mnfr.201600744
Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo [ Sci Adv, 2024, 10(7):eadk1835] | PubMed: 38354236 |
Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell [ Cell Death Dis, 2023, 14(2):142] | PubMed: 36805688 |
Luteolin inhibits herpes simplex virus 1 infection by activating cyclic guanosine monophosphate-adenosine monophosphate synthase-mediated antiviral innate immunity [ Phytomedicine, 2023, 120:155020] | PubMed: 37632997 |
Niaoduqing alleviates podocyte injury in high glucose model via regulating multiple targets and AGE/RAGE pathway: Network pharmacology and experimental validation [ Front Pharmacol, 2023, 14:1047184] | PubMed: 36923354 |
Niaoduqing alleviates podocyte injury in high glucose model via regulating multiple targets and AGE/RAGE pathway: Network pharmacology and experimental validation [ Front Pharmacol, 2023, 14:1047184] | PubMed: 36923354 |
New Insights on the Raman and SERS Spectra of Luteolin under Different Excitation Conditions: Experiments and DFT Calculations [ Chemosensors, 2023, 11(2), 104] | PubMed: none |
Luteolin inhibits A549 cells proliferation and migration by down-regulating androgen receptors [ Eur J Med Res, 2023, 28(1):353] | PubMed: 37716981 |
Investigation of the mechanism of Prunella vulgaris in treatment of papillary thyroid carcinoma based on network pharmacology integrated molecular docking and experimental verification [ Medicine (Baltimore), 2023, 102(17):e33360] | PubMed: 37115092 |
Disruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation in glioma stem cells [ Cell Death Dis, 2022, 13(5):493] | PubMed: 35610201 |
Transcriptomics and Metabolomics Identify Drug Resistance of Dormant Cell in Colorectal Cancer [ Front Endocrinol (Lausanne), 2022, 13:866641] | PubMed: 35355555 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。