受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C28H25FN6O3 |
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分子量 | 512.53 | CAS No. | 603288-22-8 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (195.11 mM) | |
Ethanol | 2 mg/mL warmed with 50ºC water bath (3.9 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases. |
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in vitro | LY2090314 selectively inhibits the activity of GSK-3 by interrupting ATP binding. LY2090314 is able to stabilize β-catenin. LY2090314 shows limited efficacy as monotherapy. LY3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro. [1] |
in vivo | LY2090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer xenografts. [1] |
細胞アッセイ | 細胞株 | A375 cells |
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濃度 | 20 nM | |
反応時間 | 5 h | |
実験の流れ | Cells were treated with various concentrations of drug for 5 h. |
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動物実験 | 動物モデル | Female athymic nude mice |
投薬量 | 25 mg/kg | |
投与方法 | i.v |
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Data from [Data independently produced by , , Cancer Res, 2017, 77(21):5873-5885]
Data from [Data independently produced by , , Mol Cancer Ther, 2016, 15(7):1485-94.]
Data from [Data independently produced by , , Stem Cell Res, 2017, 182-187]
Integrin-mediated electric axon guidance underlying optic nerve formation in the embryonic chick retina [ Commun Biol, 2023, 6(1):680] | PubMed: 37391492 |
Integrin-mediated electric axon guidance underlying optic nerve formation in the embryonic chick retina [ Commun Biol, 2023, 6(1):680] | PubMed: 37391492 |
Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis [ Cell, 2021, 184(1):243-256.e18] | PubMed: 33417861 |
ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation [ Nat Commun, 2021, 12(1):2346] | PubMed: 33879767 |
KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis [ Mol Cell, 2021, S1097-2765(21)00735-8] | PubMed: 34551282 |
GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis [ Cell Death Discov, 2021, 7(1):334] | PubMed: 34732689 |
A GSK3-SRF Axis Mediates Angiotensin II Induced Endothelin Transcription in Vascular Endothelial Cells [ Front Cell Dev Biol, 2021, 9:698254] | PubMed: 34381779 |
Glycogen synthase kinase-3 beta (GSK3β)-mediated phosphorylation of ETS1 promotes progression of ovarian carcinoma [ Aging (Albany NY), 2021, 13(10):13739-13763] | PubMed: 34023818 |
C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes [ FASEB J, 2021, 35(6):e21656] | PubMed: 34042211 |
CMTM8 as an LPA1-associated partner mediates lysophosphatidic acid-induced pancreatic cancer metastasis [ Ann Transl Med, 2021, 9(1):42] | PubMed: 33553335 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。