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Synonyms | Larixinic acid, Palatone, Veltol | Storage (From the date of receipt) |
3 years -20°C powder (seal) | |
化学式 | C6H6O3 |
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分子量 | 126.11 | CAS No. | 118-71-8 | |
Solubility (25°C)* | 体外 | DMSO | 25 mg/mL (198.23 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Maltol (Larixinic acid, Palatone, Veltol) is a naturally occurring organic compound that is flavour enhancer and flavouring agent. |
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in vitro | Maltol can effectively protect nerve cells against oxidative damage caused by ROS in order to maintain normal physiological functions of cells and inhibit diabetes-induced oxidative stress and irreversible kidney damage[1]. |
in vivo | For hepatoprotective activity in vivo, pretreatment with maltol (12.5, 25 and 50 mg/kg; 15 days) drastically prevents the elevated activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and triglyceride (TG) in serum and the levels of malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) in liver tissue. Meanwhile, the levels of hepatic antioxidant, such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) are elevated by maltol pretreatment, compared to the alcohol group. Maltol pretreatment significantly inhibits alcohol-induced hepatocyte apoptosis and fatty degeneration. It is effective in the prevention of alcohol-induced hepatic damage in mice[1]. Also, maltol is suggested to be a functional agent to prevent the oxidative damage in the brain of mice[2]. |
動物実験 | 動物モデル | Male ICR mice |
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投薬量 | 12.5, 25 and 50 mg/kg | |
投与方法 | by gastric intubation |
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長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。