Mebendazole

製品コードS4610 バッチS461002

印刷

化学情報

Chemical Structure Synonyms Mebenvet Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C16H13N3O3
分子量 295.29 CAS No. 31431-39-7
Solubility (25°C)* 体外 DMSO 8 mg/mL (27.09 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.
in vitro mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells at the G2-M phase before the onset of apoptosis. MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells[2].
in vivo When administered p.o. to nu/nu mice, MZ strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis. MZ treatment significantly reduces vessel densities in mice compared with those in control mice[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 A549, WI38 normal fibroblasts, H1299 and H460 cancer cell line
濃度 0, 0.2, 0.5, 1 μM
反応時間 48 h
実験の流れ When grown to 40–50% confluence, the cells are exposed to MZ dissolved in DMSO. Cell growth is monitored by counting the viable cells using a hemacytometer.
動物実験 動物モデル Mice
投薬量 12.5 and 25 mg/kg/day
投与方法 oral administration

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Targeting the Unwindosome by Mebendazole Is a Vulnerability of Chemoresistant Hepatoblastoma [ Cancers (Basel), 2022, 14(17)4196] PubMed: 36077733
Mebendazole Impedes the Proliferation and Migration of Pancreatic Cancer Cells through SK1 Inhibition Dependent Pathway [ Molecules, 2022, 27(23)8127] PubMed: 36500220
TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells [ Adv Biol (Weinh), 2022, 6(8):e2200030] PubMed: 35675910
The genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma [ Genome Med, 2021, 13(1):146] PubMed: 34493320
Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways [ Aging (Albany NY), 2021, 13(13):17407-17427] PubMed: 34232919
AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers [ Am J Cancer Res, 2020, 10(8):2649-2676] PubMed: 32905466
DNA methyltransferase 1-mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1-driven leukemogenesis. [ J Biol Chem, 2019, 10.1074/jbc.RA119.010144] PubMed: 31628193

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。