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Synonyms | Methyl-beta-cyclodextrin, M-β-CyD, Methyl-β-CD | Storage (From the date of receipt) |
3 years -20°C powder | ||||||||
化学式 | |||||||||||
分子量 | CAS No. | 128446-36-6 | |||||||||
Solubility (25°C)* | 体外 | Water | 100 mg/mL | ||||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Methyl-β-cyclodextrin (MβCD) is a cholesterol-removing agent mainly used for lipid raft disruption. Methyl-β-cyclodextrin induces caspase-dependent apoptosis in PEL cells and inhibits the growth and invasion of PEL cells without apparent adverse effects, suggesting the potential effective antitumor activities. |
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in vitro | Methyl-β-cyclodextrin Inhibits SDF-1α-induced platelet aggregation and Akt phosphorylation by raft disruption.[2] |
in vivo | In a Primary effusion lymphoma (PEL) xenograft mouse model, Methyl-β-cyclodextrin significantly inhibits the growth and invasion of PEL cells without apparent adverse effects. Methyl-β-cyclodextrin-treated mice appears to be healthy, whereas non-treated mice has a distended abdominal region. The body weights of control are significantly higher than those of Methyl-β-cyclodextrin treated mice. Methyl-β-cyclodextrin-treated mice has a significantly lower volume of ascites than that of non-treated mice.[1] |
細胞アッセイ | 細胞株 | Platelets |
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濃度 | 2% | |
反応時間 | 15 min | |
実験の流れ | Freshly isolated human platelets are incubated with SDF-1α and centrifuged for 1 min at 3000 rpm. The resulting pellet is resuspended and boiled in Laemmli sample buffer containing phosphatase inhibitor cocktails 2 and 3. Phosphorylations of Akt (Ser473) is detected by western blotting. Platelet aggregation is measured as the optical density of PRP during aggregation using a platelet aggregometer, with the platelet-poor plasma 100% standard for change in optical density. |
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動物実験 | 動物モデル | PEL xenograft mouse model (NOD/Rag-2/Jak3-double deficient (NRJ) mice bearing BCBL-1 cells |
投薬量 | 500 mg/kg | |
投与方法 | i.p |
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Real-Time Dissection of the Transportation and miRNA-Release Dynamics of Small Extracellular Vesicles [ Adv Sci (Weinh), 2023, 10(7):e2205566] | PubMed: 36599707 |
Exosomal miR-222-3p contributes to castration-resistant prostate cancer by activating mTOR signaling [ Cancer Sci, 2023, 114(11):4252-4269] | PubMed: 37671589 |
Porcine deltacoronavirus enters ST cells by clathrin-mediated endocytosis and does not require Rab5, Rab7, or Rab11 [ Microbiol Spectr, 2023, 10.1128/spectrum.02553-23] | PubMed: 37962380 |
Evaluation of the liver targeting and anti‑liver cancer activity of artesunate‑loaded and glycyrrhetinic acid‑coated nanoparticles [ Exp Ther Med, 2023, 26(5):516] | PubMed: 37854499 |
CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids [ Nat Commun, 2022, 13(1):2407] | PubMed: 35504891 |
Channel catfish virus entry into host cells via clathrin-mediated endocytosis [ Virus Res, 2022, 315:198794] | PubMed: 35504448 |
Porcine Deltacoronavirus (PDCoV) Entry into PK-15 Cells by Caveolae-Mediated Endocytosis [ Viruses, 2022, 14(3)496] | PubMed: 35336903 |
VPS34 regulates dynamin to determine the endocytosis of mitochondria-targeted zinc oxide nanoparticles in human osteosarcoma cells [ J Mater Chem B, 2021, 9(11):2641-2655] | PubMed: 33683276 |
Time-Dependent Internalization of S100B by Mesenchymal Stem Cells via the Pathways of Clathrin- and Lipid Raft-Mediated Endocytosis [ Front Cell Dev Biol, 2021, 9:674995] | PubMed: 34381770 |
A strategy for developing effective orally-delivered nanoparticles through modulation of the surface "hydrophilicity/hydrophobicity balance" [ J Mater Chem B, 2017, 5(6):1302-1314] | PubMed: 32263598 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。