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化学情報
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder (seal) |
| 化学式 | C29H35N2O2P.Cl |
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| 分子量 | 510.03 | CAS No. | 1334850-99-5 | |
| Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (196.06 mM) | |
| Water | 100 mg/mL (196.06 mM) | |||
| Ethanol | 100 mg/mL (196.06 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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溶剤液（一定の濃度）を調合する
生物活性
| 製品説明 | Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression. |
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| in vitro | Mito-TEMPO improves blastocyst development by superoxide reduction in porcine embryos in vitro.[2] |
| in vivo | Mito-Tempo (MT) treatment inhibits APAP-induced RIP3 kinase expression, and RIP3-deficient mice shows caspase activation and apoptotic morphology in hepatocytes analogous to MT treatment.[1] |
プロトコル(参考用のみ)
| 細胞アッセイ | 細胞株 | Porcine embryos |
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| 濃度 | 0.1 μM | |
| 反応時間 | -- | |
| 実験の流れ | Embryos are cultured in 50 μl drops porcine zygote medium-3 (PZM-3) with 3 mg/ml BSA at 38.5 °C under 5% CO2. After culturing 48 hours, cleaved embryos are transferred to 50 μl drop of fresh PZM-3 medium and cultured for 4 days. Blastocyst formation is evaluated after 6 days of culture. Mito-TEMPO (0.1 μM) is added to the culture medium during the IVC periods. |
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| 動物実験 | 動物モデル | 8-12 week-old male C57BL/6J mice |
| 投薬量 | 20 mg/kg | |
| 投与方法 | IP |
参考
|
Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：
| Gonococcal OMV-delivered PorB induces epithelial cell mitophagy [ Nat Commun, 2024, 15(1):1669] | PubMed: 38396029 |
| Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway [ Exp Mol Med, 2024, 56(2):408-421.] | PubMed: 38316963 |
| C5b-9 promotes ferritinophagy leading to ferroptosis in renal tubular epithelial cells of trichloroethylene-sensitized mice [ Sci Total Environ, 2024, 923:171378] | PubMed: 38447712 |
| Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling [ Cell Mol Life Sci, 2024, 81(1):88] | PubMed: 38349408 |
| Loss of Myo19 increases metastasis by enhancing microenvironmental ROS gradient and chemotaxis [ EMBO Rep, 2024, 10.1038/s44319-023-00052-y] | PubMed: 38279020 |
| Tumor cell-intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling [ Sci Adv, 2024, 10(3):eadi2012] | PubMed: 38241371 |
| Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma [ Redox Biol, 2023, 62:102687] | PubMed: 36989574 |
| Metabolic reprogramming induced by DCA enhances cisplatin sensitivity through increasing mitochondrial oxidative stress in cholangiocarcinoma [ Front Pharmacol, 2023, 14:1128312] | PubMed: 37818192 |
| Metabolic reprogramming induced by DCA enhances cisplatin sensitivity through increasing mitochondrial oxidative stress in cholangiocarcinoma [ Front Pharmacol, 2023, 14:1128312] | PubMed: 37818192 |
| Targeting Wnt/β-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF [ Cells, 2022, 11(22)3580] | PubMed: 36429010 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。