Molsidomine

製品コードS4664 バッチS466401

化学情報

	Synonyms	SIN-10, Corvaton, Morsydomine	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₉H₁₄N₄O₄
	分子量	242.23	CAS No.	25717-80-0
Solubility (25°C)*	体外	DMSO	48 mg/mL (198.15 mM)
		Ethanol	48 mg/mL (198.15 mM)
		Water	9 mg/mL (37.15 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Molsidomine (SIN-10, Corvaton, Morsydomine) is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
in vivo	Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by molsidomine. Molsidomine decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by molsidomine. Stroke volume and cardiac output fall after molsidomine. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart^[1].

製品説明

Molsidomine (SIN-10, Corvaton, Morsydomine) is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

in vivo

Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by molsidomine. Molsidomine decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by molsidomine. Stroke volume and cardiac output fall after molsidomine. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart^[1].

プロトコル(参考用のみ)

動物実験	動物モデル	Adult mongrel dogs
	投薬量	50, 100, 250 μg/kg
	投与方法	i.v.

参考

[1] Volker B. Fiedler, et al. Naunyn-Schmiedeberg's Archives of Pharmacology. 1981, 317(1):71-77.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

C-Type Lectin Receptor CD23 Is Required for Host Defense against Candida albicans and Aspergillus fumigatus Infection. [ J Immunol, 2018, 201(8):2427-2440]	PubMed: 30185519

C-Type Lectin Receptor CD23 Is Required for Host Defense against Candida albicans and Aspergillus fumigatus Infection. [ J Immunol, 2018, 201(8):2427-2440]

PubMed: 30185519

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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