Mometasone furoate

Mometasone furoate efficiently suppresses production of cytokines including interleukin (IL)-4, IL-5, and interferon-gamma in anti-CD3-stimulated human CD4+ T cells. Mometasone furoate effectively inhibits the activation of Th cells including type 2 Th (Th2) in the draining LN, thus leading to the suppression of the IgE response. ^[1]

Mometasone causes a decrease in the instances of nasal rubbing and an inhibition of this response is observed during the treatment period in rats. ^[2] Mometasone (3 mg/kg) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested in mice. Mometasone, given an hour after the last allergen challenge, dose-dependently inhibits the allergen-induced increase in Penh with about a 10-fold loss of potency when compared with the pre-challenge treatment schedule. ^[3] Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibits the increase of antigen-induced nasal rubbing even 6 hours after topical application, indicating that both drugs have a long-lasting effect. ^[4] Mometasone furoate dose-dependently inhibits the elevated eosinophil numbers in the bronchoalveolar lavage fluid and lung tissues of sensitized, ovalbumin challenged mice. Mometasone furoate (33 mg/kg) reduces the percentage of CD44+ T-helper cells (activated/memory cells) to the levels observed in non-sensitized, ovalbumin-challenged mice. ^[5]

• [1] Magari M, et al. Immunopharmacol Immunotoxicol,?006, 28(3), 491-500.
• [2] Tsumuro T, et al. Eur J Pharmacol,?005, 524(1-3), 155-158.
• [3] Wyss D, et al. Br J Pharmacol,?007, 152(1), 83-90.

• [4] Sugimoto Y, et al. Pharmacology,?000, 61(2), 91-95.
• [5] Chapman RW, et al. Arzneimittelforschung,?998, 48(4), 384-391.

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