N-Acetylcysteine amide

製品コードS5804 バッチS580401

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C5H10N2O2S
分子量 162.21 CAS No. 38520-57-9
Solubility (25°C)* 体外 DMSO 32 mg/mL (197.27 mM)
Water 32 mg/mL (197.27 mM)
Ethanol 13 mg/mL (80.14 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.
in vitro

The antioxidant N-acetylcysteine (NAC) blocks erastin-induced or RSL3-induced cell death in Nupr1-/- mPDAC cells, an effect that is associated with decreased production or release of MDA, 8-OHdG, or HMGB1. NUPR1-knockdown PANC1 cells exhibits increased MDA, 8-OHdG, and HMGB1 release during ferroptotic cell death, which can be reversed by the addition of NAC.[2]
in vivo

Combined n-acetylcysteine (NAC) and bone marrow-derived mesenchymal stem cells (BMSCs) therapy alleviates oxidative stress damage to the pancreas and inhibits the inflammatory response to a significantly greater extent than single therapy with either BMSCs or NAC.[3]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 mPDAC cells
濃度 1 mM
反応時間 24 h
実験の流れ

Indicated mPDAC cells are treated with erastin (10 μM) or RSL3 (1 μM) in the absence or presence of DFO (100 M) or N-acetylcysteine (1 mM) for 24 h, and then intracellular MDA, intracellular 8-OHdG, extracellular HMGB1, and cell viability are assayed by a CCK8 kit.
動物実験 動物モデル Male Sprague-Dawley (SD) rats of severe acute pancreatitis (SAP) models
投薬量 100 mg/kg
投与方法 i.p.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons [ Nat Commun, 2023, 14(1):5165] PubMed: 37620297
Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons [ Nat Commun, 2023, 14(1):5165] PubMed: 37620297
Omicron Spike Protein is Vulnerable to Reduction [ J Mol Biol, 2023, 435(13):168128] PubMed: 37100168
Comprehensive analysis of cuproptosis-related lncRNAs for prognostic significance and immune microenvironment characterization in hepatocellular carcinoma [ Front Immunol, 2022, 13:991604] PubMed: 36685508
NUPR1 is a critical repressor of ferroptosis [ Nat Commun, 2021, 12(1):647] PubMed: 33510144
Angiotensin II inhibits osteogenic differentiation of isolated synoviocytes by increasing DKK-1 expression. [ Int J Biochem Cell Biol, 2020, 121:105703] PubMed: 32014499
N-Acetylcysteine enhances the therapeutic efficacy of bone marrow-derived mesenchymal stem cell transplantation in rats with severe acute pancreatitis. [ Pancreatology, 2019, 19(2):258-265] PubMed: 30660392
Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells. [ Biochem Biophys Res Commun, 2019, 508(4):1271-1278] PubMed: 30573364
pH Sensitive Triptolide-Loaded Liposome Calcium Phosphate Nanoparticles Exhibit Enhanced Anti-Tumor Activities Against Ovarian Cancer Without Damaging the Reproductive System. [ J Biomed Nanotechnol, 2017, 13(11):1413-1424] PubMed: 31271128

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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