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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C5H10N2O2S |
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分子量 | 162.21 | CAS No. | 38520-57-9 | |
Solubility (25°C)* | 体外 | DMSO | 32 mg/mL (197.27 mM) | |
Water | 32 mg/mL (197.27 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. |
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in vitro | The antioxidant N-acetylcysteine (NAC) blocks erastin-induced or RSL3-induced cell death in Nupr1-/- mPDAC cells, an effect that is associated with decreased production or release of MDA, 8-OHdG, or HMGB1. NUPR1-knockdown PANC1 cells exhibits increased MDA, 8-OHdG, and HMGB1 release during ferroptotic cell death, which can be reversed by the addition of NAC.[2] |
in vivo | Combined n-acetylcysteine (NAC) and bone marrow-derived mesenchymal stem cells (BMSCs) therapy alleviates oxidative stress damage to the pancreas and inhibits the inflammatory response to a significantly greater extent than single therapy with either BMSCs or NAC.[3] |
細胞アッセイ | 細胞株 | mPDAC cells |
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濃度 | 1 mM | |
反応時間 | 24 h | |
実験の流れ | Indicated mPDAC cells are treated with erastin (10 μM) or RSL3 (1 μM) in the absence or presence of DFO (100 M) or N-acetylcysteine (1 mM) for 24 h, and then intracellular MDA, intracellular 8-OHdG, extracellular HMGB1, and cell viability are assayed by a CCK8 kit. |
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動物実験 | 動物モデル | Male Sprague-Dawley (SD) rats of severe acute pancreatitis (SAP) models |
投薬量 | 100 mg/kg | |
投与方法 | i.p. |
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Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons [ Nat Commun, 2023, 14(1):5165] | PubMed: 37620297 |
Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons [ Nat Commun, 2023, 14(1):5165] | PubMed: 37620297 |
Omicron Spike Protein is Vulnerable to Reduction [ J Mol Biol, 2023, 435(13):168128] | PubMed: 37100168 |
Comprehensive analysis of cuproptosis-related lncRNAs for prognostic significance and immune microenvironment characterization in hepatocellular carcinoma [ Front Immunol, 2022, 13:991604] | PubMed: 36685508 |
NUPR1 is a critical repressor of ferroptosis [ Nat Commun, 2021, 12(1):647] | PubMed: 33510144 |
Angiotensin II inhibits osteogenic differentiation of isolated synoviocytes by increasing DKK-1 expression. [ Int J Biochem Cell Biol, 2020, 121:105703] | PubMed: 32014499 |
N-Acetylcysteine enhances the therapeutic efficacy of bone marrow-derived mesenchymal stem cell transplantation in rats with severe acute pancreatitis. [ Pancreatology, 2019, 19(2):258-265] | PubMed: 30660392 |
Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells. [ Biochem Biophys Res Commun, 2019, 508(4):1271-1278] | PubMed: 30573364 |
pH Sensitive Triptolide-Loaded Liposome Calcium Phosphate Nanoparticles Exhibit Enhanced Anti-Tumor Activities Against Ovarian Cancer Without Damaging the Reproductive System. [ J Biomed Nanotechnol, 2017, 13(11):1413-1424] | PubMed: 31271128 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。