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Synonyms | PTI-901 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C20H23NO4.HCl |
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分子量 | 377.86 | CAS No. | 16676-29-2 | |
Solubility (25°C)* | 体外 | DMSO | 75 mg/mL (198.48 mM) | |
Water | 75 mg/mL (198.48 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Naltrexone HCl(PTI-901) is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. |
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in vivo | Naltrexone (0.32 mg/kg) reduces ethanol-reinforced responding at the concentration that maintained the most responding (1% or 2%) in rhesus monkeys. Naltrexone (0.1 mg/kg) reduces ethanol-reinforced responding, both at a low ethanol concentration (0.25%) that produced little ethanol intake (g/kg), and at a higher concentration (4%) with an appreciable intake. [1] Naltrexone (1-3 mg/kg) potently and dose-dependently inhibits reinstatement of ethanol-seeking produced by non-contingent deliveries of the liquid dipper filled with 8% ethanol. [2] Naltrexone elicits optimal enhancement of morphine's antinociceptive potency in mice when co-administered (i.p.) at about 100 ng/kg together with morphine (3 mg/kg). [3] Naltrexone (10 ng/kg i.p.) augments the antinociception produced by an acute submaximal dose of intrathecal (5 mg) or systemic (7.5 mg/kg i.p.) morphine in the tail-flick test in rats. Naltrexone combined with Morphine inhibits the decline in morphine antinociception and prevented the loss of morphine potency in rats. [4] Naltrexone significantly suppresses ethanol self-administration and prevents ethanol-induced increases in dialysate dopamine levels. [5] Naltrexone completely prevents the reduction in anogenital distance in prenatally stressed (PS) males and restores the growth rate of both sexes. Naltrexone also decreases the anxiety of PS rats in the plus-maze, increases the opioid component of exploration to control levels, but increases anxiety in control males. [6] |
, , Photodermatol Photoimmunol Photomed, 2016, 32(3):136-45.
Data from [Data independently produced by , , Photodermatol Photoimmunol Photomed, 2017, 33(2):84-91]
Molecular mechanisms involved in alcohol craving, IRF3, and endoplasmic reticulum stress: a multi-omics study [ Transl Psychiatry, 2024, 14(1):165] | PubMed: 38531832 |
Dezocine induces apoptosis in human cervical carcinoma Hela cells via the endoplasmic reticulum stress pathway [ Toxicol Res (Camb), 2022, 11(3):498-510] | PubMed: 35782639 |
The role of orphan receptor GPR139 in neuropsychiatric behavior [ Neuropsychopharmacology, 2021, 10.1038/s41386-021-00962-2] | PubMed: 33479510 |
G-Protein-Coupled Estrogen Receptor (GPER) in the Rostral Ventromedial Medulla Is Essential for Mobilizing Descending Inhibition of Itch [ J Neurosci, 2021, 41(37):7727-7741] | PubMed: 34349001 |
N-Demethylsinomenine, an active metabolite of sinomenine, attenuates chronic neuropathic and inflammatory pain in mice [ Sci Rep, 2021, 11(1):9300] | PubMed: 33927244 |
The evolution of a series of behavioral traits is associated with autism-risk genes in cavefish. [ BMC Evol Biol, 2018, 18(1):89] | PubMed: 29909776 |
Ultraviolet A eye irradiation ameliorates colon carcinoma induced by azoxymethane and dextran sodium sulfate through β-endorphin and methionine-enkephalin. [Hiramoto K, et al. Photodermatol Photoimmunol Photomed, 2017, 33(2):84-91] | PubMed: 28039905 |
The gender differences in the inhibitory action of UVB-induced melanocyte activation by the administration of tranexamic acid [ Photodermatol Photoimmunol Photomed, 2016, 32(3):136-45] | PubMed: 26663237 |
The gender differences in the inhibitory action of UVB-induced melanocyte activation by the administration of tranexamic acid [Hiramoto K, et al. Photodermatol Photoimmunol Photomed, 2015, 10.1111/phpp.12231] | PubMed: 26663237 |
Antinociceptive effects of sinomenine in a rat model of neuropathic pain. [Zhu Q, et al. Sci Rep, 2014, 4:7270] | PubMed: 25434829 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。