Naringenin

製品コードS2394 バッチS239402

印刷

化学情報

Chemical Structure Synonyms NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol Storage
(From the date of receipt)		 3 years -20°C powder (seal)
化学式

C15H12O5
分子量 272.25 CAS No. 480-41-1
Solubility (25°C)* 体外 DMSO 54 mg/mL (198.34 mM)
Ethanol 5 mg/mL (18.36 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
in vitro Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Naringenin is the predominant flavanone in grapefruit. This substance has also been shown to reduce oxidative damage to DNA in vitro. Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2, which can change pharmacokinetics in a human (or orthologous) host of several popular agents in an adverse manner, even resulting in carcinogens of otherwise harmless substances. [1]
in vivo Intragastrically administered Naringenin (50 mg/kg) induces a significant decrease in plasma glucose in normoglycaemic and non-insulin-dependent diabetes mellitus (NIDDM) rat models. LD50: Mice >5g/kg; Rats >5g/kg. [2]

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [Data independently produced by , , Scientific Reports 6, 2016, Article number: 27268 ]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Targeting of mitochondrial fission through natural flavanones elicits anti-myeloma activity [ J Transl Med, 2024, 22(1):208] PubMed: 38413989
Synergism Antiproliferative Effects of Apigenin and Naringenin in NSCLC Cells [ Molecules, 2023, 28(13)4947] PubMed: 37446609
Network-Based Pharmacology and Bioinformatics Study on the Mechanism of Action of Gujiansan in the Treatment of Steroid-Induced Avascular Necrosis of the Femoral Head [ Biomed Res Int, 2022, 2022:8080679] PubMed: 35915795
Naringenin alleviates obesity-associated hypertension by reducing hyperlipidemia and oxidative stress [ Kidney Blood Press Res, 2022, 10.1159/000524172] PubMed: 35354142
Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors [ Int J Mol Sci, 2020, 21(14):5025] PubMed: 32708687
Aloperine inhibits hepatitis C virus entry into cells by disturbing internalisation from endocytosis to the membrane fusion process [ Eur J Pharmacol, 2020, 173323] PubMed: 32622669
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754
Naringenin ameliorates insulin resistance by modulating endoplasmic reticulum stress in hepatitis C virus-infected liver. [ Biomed Pharmacother, 2019, 115:108848] PubMed: 31039496
Naringenin improve hepatitis C virus infection induced insulin resistance by increase PTEN expression via p53-dependent manner. [ Biomed Pharmacother, 2018, 103:746-754] PubMed: 29684853
A Schisandra-Derived Compound Schizandronic Acid Inhibits Entry of Pan-HCV Genotypes into Human Hepatocytes. [Qian XJ, et al. Sci Rep, 2016, 6:27268] PubMed: 27252043

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。