受注:045-509-1970 |
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Synonyms | RG 6078, NLG-919 analogue, GDC-0919 analogue | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C18H22N2O |
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分子量 | 282.38 | CAS No. | 1402836-58-1 | |
Solubility (25°C)* | 体外 | DMSO | 56 mg/mL warmed with 50ºC water bath (198.31 mM) | |
Ethanol | 30 mg/mL (106.23 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM. |
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in vitro | IDO-IN-2 (NLG-919 analogue, Compound 24) contains an imidazoleisoindole core and exhibits potent inhibitory activity to IDO1 with the IC50 value of 38 nM. IDO-IN-2 inhibits IDO activity with EC50 of 61 nM in HeLa cellular assay. The binding mode of IDO-IN-2 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme.[2] IDO-IN-2 (Compound 7) has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier.[1] |
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Data from [J Biomol Screen, 2014, 10.1177/1087057114536616]
Data from [Data independently produced by , , Biochem Pharmacol, 2018, 158:286-297]
Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy [ Acta Pharm Sin B, 2022, 12(6):2695-2709] | PubMed: 35755274 |
Cascade Immune Activation of Self-Delivery Biomedicine for Photodynamic Immunotherapy Against Metastatic Tumor [ Small, 2022, e2205694] | PubMed: 36366925 |
Downregulation of miR-26 promotes invasion and metastasis via targeting interleukin-22 in cutaneous T-cell lymphoma [ Int J Mol Sci, 2022, 23(7)3981] | PubMed: 35409342 |
Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation [ J Immunother Cancer, 2021, 9(7)e002840] | PubMed: 34326168 |
Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza [ Eur Respir J, 2020, 2000443] | PubMed: 33243840 |
Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition [ ACS Nano, 2020, 14(7):8985-8999] | PubMed: 32662971 |
Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase 1 (HDAC1) Dual Inhibitors Derived from the Natural Product Saprorthoquinone [ Molecules, 2020, 25(19)E4494] | PubMed: 33007982 |
Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase 1 (HDAC1) Dual Inhibitors Derived from the Natural Product Saprorthoquinone [ Molecules, 2020, 25(19)E4494] | PubMed: 33007982 |
Inhibition of the BET family reduces its new target gene IDO1 expression and the production of L-kynurenine. [ Cell Death Dis, 2019, 10(8):557] | PubMed: 31324754 |
Displacement Induced Off-On Fluorescent Biosensor Targeting IDO1 Activity in Live Cells. [ Anal Chem, 2019, 91(23):14943-14950] | PubMed: 31714063 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。