OSS_128167

製品コードS8627 バッチS862701

化学情報

	Synonyms	SIRT6-IN-1	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₉H₁₄N₂O₆
	分子量	366.32	CAS No.	887686-02-4
Solubility (25°C)*	体外	DMSO	73 mg/mL (199.27 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.
in vitro	OSS-128167 is a selective compounds toward SIRT6 with IC50 values toward SIRT1 and SIRT2 being approximately 20 times higher. It is cell permeable and active in cultured cells. OSS-128167 increases H3K9 acetylation and GLUT-1 expression^[1].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BxPC3 cells
	濃度	100 μM
	反応時間	0, 2, 6, 18, 24 h
	実験の流れ	4 × 10⁵ BxPC3 cells are plated in six-well plates and allowed to adhere for 24 h. Thereafter, cells are stimulated with 100 μM OSS-128167 or the respective amounts of vehicle DMSO for the indicated time amounts. Finally, cells are used for protein lysate generation, and total H3 and acetylated H3K9 levels are detected by immunoblotting.

参考

[1] Parenti MD, et al. J Med Chem. 2014, 57(11):4796-804.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery [ Antioxidants (Basel), 2023, 12(3)714]	PubMed: 36978961
Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury via SIRT6-Mediated Autophagy Activation [ Oxid Med Cell Longev, 2022, 2022:9035547]	PubMed: 36160707
SIRT6 regulates obesity-induced oxidative stress via ENDOG/SOD2 signaling in the heart [ Cell Biol Toxicol, 2022, 10.1007/s10565-022-09735-z]	PubMed: 35798905
Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress [ Biochem Pharmacol, 2022, 199:115022]	PubMed: 35358477
Downregulation of Sirt6 by CD38 promotes cell senescence and aging [ Aging (Albany NY), 2022, 14(23):9730-9757]	PubMed: 36490326
Downregulation of Sirt6 by CD38 promotes cell senescence and aging [ Aging (Albany NY), 2022, 14(23):9730-9757]	PubMed: 36490326
Deacetylation of ATG4B promotes autophagy initiation under starvation [ Sci Adv, 2022, 8(31):eabo0412]	PubMed: 35921421
Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1 [ NPJ Precis Oncol, 2021, 5(1):20]	PubMed: 33742100
SIRT6 Maintains Redox Homeostasis to Promote Porcine Oocyte Maturation [ Front Cell Dev Biol, 2021, 9:625540]	PubMed: 33718364
SIRT6 Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Through Antagonizing DNMT1 [ Front Cell Dev Biol, 2021, 9:648627]	PubMed: 34239868

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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