Oxibendazole

製品コードS1851 バッチS185101

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₂H₁₅N₃O₃
	分子量	249.27	CAS No.	20559-55-1
Solubility (25°C)*	体外	4-Methylpyridine	4 mg/mL warmed with 50ºC water bath (16.04 mM)
		DMSO	1 mg/mL (4.01 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明	Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.
in vivo	Oxibendazole shows a significant reduction of the proportion of positive foals after treatment. Oxibendazole significantly reduces the proportion of positive horse foals on six of the seven farms (86%). ^[1] Oxibendazole reduces in the number of strongyle eggs/g (epg) in horse, but the reduction is only by 82% with an upper confidence limit of 89%. ^[2] Oxibendazole results in collapse of the lip papillae, rupture of buccal cavity cuticle, prolapse of the pharynx, degeneration of epithelial cells and erosion of microvilli in adult Ascaris suum, theses changes may lead to impaired digestion and absorption of nutrients and cause cellular autolysis, resulting in the death of the worm. ^[3] Oxibendazole reduces faecal worm egg counts (EPG) by 97.6% for Toxocara canis, 95.7% for Trichuris vulpis, 94.6% for Ancylostoma caninum, and 100% for Toxascaris leonine in dogs and cats. ^[4] Oxibendazole could only be detected in plasma at the 0.5 hours and 1.0 hours post administration sampling times and the mean maximum plasma concentration is 0.008 mg/mL in horse. Oxibendazole is detected in faeces between 12 and 72 hours after administration and the highest dry faecal concentration was detected at 24 hours. ^[5]

製品説明

Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.

in vivo

Oxibendazole shows a significant reduction of the proportion of positive foals after treatment. Oxibendazole significantly reduces the proportion of positive horse foals on six of the seven farms (86%). ^[1] Oxibendazole reduces in the number of strongyle eggs/g (epg) in horse, but the reduction is only by 82% with an upper confidence limit of 89%. ^[2] Oxibendazole results in collapse of the lip papillae, rupture of buccal cavity cuticle, prolapse of the pharynx, degeneration of epithelial cells and erosion of microvilli in adult Ascaris suum, theses changes may lead to impaired digestion and absorption of nutrients and cause cellular autolysis, resulting in the death of the worm. ^[3] Oxibendazole reduces faecal worm egg counts (EPG) by 97.6% for Toxocara canis, 95.7% for Trichuris vulpis, 94.6% for Ancylostoma caninum, and 100% for Toxascaris leonine in dogs and cats. ^[4] Oxibendazole could only be detected in plasma at the 0.5 hours and 1.0 hours post administration sampling times and the mean maximum plasma concentration is 0.008 mg/mL in horse. Oxibendazole is detected in faeces between 12 and 72 hours after administration and the highest dry faecal concentration was detected at 24 hours. ^[5]

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Oxibendazole inhibits prostate cancer cell growth. [ Oncol Lett, 2018, 15(2):2218-2226]	PubMed: 29434928

Oxibendazole inhibits prostate cancer cell growth. [ Oncol Lett, 2018, 15(2):2218-2226]

PubMed: 29434928

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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