Oxybenzone

製品コードS4691 バッチS469101

印刷

化学情報

Chemical Structure Synonyms Eusolex 4360, Escalol 567, KAHSCREEN BZ-3, Benzophenone 3 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C14H12O3
分子量 228.24 CAS No. 131-57-7
Solubility (25°C)* 体外 DMSO 45 mg/mL (197.16 mM)
Ethanol 45 mg/mL (197.16 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Oxybenzone (Eusolex 4360, Escalol 567, KAHSCREEN BZ-3, Benzophenone 3) is a benzophenone derivative used as a sunscreen agent.
in vitro A dose-dependent inhibition of PGE2-production is found in the HEPM cell culture following oxybenzone exposure[1]. Benzophenones, including oxybenzone(BP-3) are documented mutagens that increase the rate of damage to DNA, especially when exposed to sunlight. It either can act directly as genotoxicants or become genotoxicants by bioactivation via cytochrome P450 enzymes. Oxybenzone can generate reactive oxygen species, which are potential mutagens, when applied topically to the skin followed by UV light exposure[2].
in vivo In mice studies, oxybenzone(BP-3) exposure significantly affects fecundity, as well as inducing unexplained mortality in lactating mothers. Studies in both mice and rats demonstrate that generational exposure to oxybenzone(BP-3) reduces body weight, increases liver ([50 %) and kidney weights, induces a 30 % increase in prostate weight, a reduction in immunocompetence, and significantly increases uterine weight in juveniles. In mammals, oxybenzone(BP-3) is renowned for having estrogenic and anti-androgenic activities, causing activation of estrogen receptor proteins and inhibition of androgen receptors[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Human embryo palatal mesenchyme cells
濃度 0.01-50 μM
反応時間 24 h
実験の流れ

Cells are grown at 37℃ with 100% humidity and 10% CO2. Prior to analyses, cells are subcultured onto 24-well plates and allowed to become 70-90% confluent. On day 1 of the experiment, cells are washed three times with serum-free media containing 0.5% bovine serum albumin (BSA), followed by replacement with the same media that also contained 1 ng/ml of IL-1β with or without oxybenzone. After an exposure time of 24 h, the media are removed, the pH adjusted to 3.5 with HCl, and finally assayed for PGE2-production.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Melatonin protects against oxybenzone-induced deterioration of mouse oocytes during maturation [ Aging (Albany NY), 2020, 13(2):2727-2749] PubMed: 33373318

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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