受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | 4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
|
化学式 | C9H8O3 |
|||
分子量 | 164.16 | CAS No. | 501-98-4 | |
Solubility (25°C)* | 体外 | DMSO | 32 mg/mL (194.93 mM) | |
Ethanol | 32 mg/mL (194.93 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity. |
---|---|
in vitro | p-Coumaric acid is the most abundant isomer in natureand is biosynthesized from cinnamic acid by the action ofthe P450-dependent enzyme 4-cinnamic acid hydroxylase. p-Coumaric acid possesses antioxidant properties that reduce the risk of stomachcancer by suppressing the formation of carcinogenic nitrosamines. p-coumaric acid effectively suppressed endo-thelial cell migration, tube formation, and rat aorta ring sprouting. It reduces intracellular andmitochondrial reactive oxygen species production[1]. |
in vivo | p-coumaric acid signif-icantly suppressed tumor growth in vivo by blockingangiogenesis[1]. |
細胞アッセイ | 細胞株 | ECV304 cells |
---|---|---|
濃度 | 0-5 mM | |
反応時間 | 24 h | |
実験の流れ | ECV304 cells were seededat a concentration of 6.0 ×104 cells/cm2 onto 24-well plates. After specific treatment for 24 h, a final concentration of 0.5 mg/mL MTT reagent was added directly toeach well. After 2 h, the medium was removed, the formazan crystals in ECV304 cells were dissolved in dimethylsulfoxide, and the absorbance of the formazan solutionwas measured by an ELISA reader at 540 nm. |
|
動物実験 | 動物モデル | Male BALB/c mice |
投薬量 | 150 mg/kg | |
投与方法 | i.p. |
Combination of HDE and BIIB021 efficiently inhibits cell proliferation and induces apoptosis via downregulating hTERT in myelodysplastic syndromes [ Exp Ther Med, 2021, 21(5):503] | PubMed: 33791012 |
Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster. [ J Nutr Biochem, 2015, 26(11):1379-84] | PubMed: 26303405 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。