Palmatine

製品コードS3769 バッチS376902

化学情報

	Synonyms	Berbericinine, Burasaine	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₁H₂₂NO₄
	分子量	352.4	CAS No.	3486-67-7
Solubility (25°C)*	体外	DMSO	70 mg/mL (198.63 mM)
		Water	20 mg/mL (56.75 mM)
		Ethanol	12 mg/mL (34.05 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.
in vitro	Palmatine plays an important role in osteoclast apoptosis via the NOS system in osteoclasts^[1]. Palmatine has been reported to possess sedative and antioxidant activities. It has been also shown to be inhibitor of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE 1), acetyl- and butyrylcholinesterases (AChE and BChE)^[2].
in vivo	Palmatine shows memory enhancing activity in mice probably by inhibiting brain acetylcholinesterase activity, through involvement of GABA-benzodiazepine pathway and due to its antioxidant activity^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	RAW 264.7 cells
	濃度	1, 5, 10, 40, and 100 µM
	反応時間	24 h or 5 days
	実験の流れ	Cell viability is measured using the cell counting kit-8 (CCK-8). The cells are seeded in a 96-well flat-bottomed microplate (5 × 10³ cells/well) and cultured in 100 μL of growth medium at 37°C and 5% CO2 for 24 h or 5 days. The cell culture medium in each well is then replaced with 100 μL of cell growth medium containing palmatine at the following concentrations: 1, 5, 10, 40, and 100 µM. Additionally, L-NAME (10, 100, and 1000 μM) dissolved in PBS was added. After incubation for 24 h or 5 days at 37°C, the cells are washed with PBS 3 times. Then, 10 μL of CCK-8 dye and 100 μL of α-MEM cell culture medium are added to each well, and cells are incubated for another 1 h at 37°C. Cell viability (%) is calculated.
動物実験	動物モデル	Swiss young male albino mice
	投薬量	0.1, 0.5, 1 mg/kg
	投与方法	i.p.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Palmatine alleviates cardiac fibrosis by inhibiting fibroblast activation through the STAT3 pathway [ Eur J Pharmacol, 2024, 967:176395]	PubMed: 38350592

Palmatine alleviates cardiac fibrosis by inhibiting fibroblast activation through the STAT3 pathway [ Eur J Pharmacol, 2024, 967:176395]

PubMed: 38350592

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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