Pantoprazole

製品コードS2105 バッチS210501

印刷

化学情報

Chemical Structure Synonyms SKFSKF96022, BY-1023 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C16H15F2N3O4S
分子量 383.37 CAS No. 102625-70-7
Solubility (25°C)* 体外 DMSO 76 mg/mL (198.24 mM)
Ethanol 76 mg/mL (198.24 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.
in vitro PPZ(Pantoprazole) inhibits the proliferation of tumor cells, induces apoptosis and downregulates the expression of PKM2, which contributes to the current understanding of the functional association between PPZ and PKM2(The human M2 isoform of pyruvate kinase)[2]. Ex vivo studies showed that pantoprazole inhibited TOPK activities in JB6 Cl41 cells and HCT 116 colorectal cancer cells. Moreover, knockdown of TOPK in HCT 116 cells decreased their sensitivities to pantoprazole[3].
in vivo i.p. injection of pantoprazole in HCT 116 colon tumor-bearing mice effectively suppresses cancer growth. The TOPK downstream signaling molecule phospho-histone H3 in tumor tissues is also decreased after pantoprazole treatment[3]. At higher infusion rates, pantoprazole is able to induce negative hemodynamic responses, in particular, in the setting of heart failure. These effects can lead to significant impairment of cardiac function[4]. Also, pantoprazole delays fracture healing by affecting both bone formation and bone remodeling[5].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 SGC-7901 cells
濃度 5 mg/ml
反応時間 24 h
実験の流れ

The SGC-7901 cells are seeded in 100 µl of medium per well, at a density of 1x104/well, in 96-well plates and treated with 5 mg/ml PPZ for 24 h. The cytotoxicity of PPZ is assessed by a cell counting kit-8 assay. The cytotoxicity is expressed as the relative cell viability, using the following formula: Cell viability (%) = (OD of drug-treated sample/OD of untreated sample) x 100. The experiment is repeated 3 times.
動物実験 動物モデル Non-obese Diabetic/Severe Combined Immunodeficiency (NOD-SCID) mice
投薬量 100 mg/kg
投与方法 i.p.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Hyperglycemia in Pregnancy-Associated Oxidative Stress Augments Altered Placental Glucose Transporter 1 Trafficking via AMPKα/p38MAPK Signaling Cascade [ Int J Mol Sci, 2022, 23-158572] PubMed: 35955706
Evaluation of an Ussing Chamber System Equipped with Rat Intestinal Tissues to Predict Intestinal Absorption and Metabolism in Humans [ Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x] PubMed: 35733077
Ilaprazole and other novel prazole-based compounds that bind Tsg101 inhibit viral budding of HSV-1/2 and HIV from cells [ J Virol, 2021, JVI.00190-21] PubMed: 33731460
Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2. [ Front Microbiol, 2019, 10:2790] PubMed: 31849920

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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