BMS202

製品コードS7912 バッチS791201

化学情報

	Synonyms	PD-1/PD-L1 inhibitor 2	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₅H₂₉N₃O₃
	分子量	419.52	CAS No.	1675203-84-5
Solubility (25°C)*	体外	DMSO	83 mg/mL (197.84 mM)
		Ethanol	83 mg/mL (197.84 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	BMS202 is a small-molecule PD-1/PD-L1 interaction inhibitor with IC50 of 18 nM.
in vitro	BMS-202 inhibits PD-1/PD-L1 binding in SCC-3 and Jurkat cells with IC50 of 15 μM and 10 μM, respectively.
in vivo	BMS-202 treatment shows a clear antitumor effect compared with the controls, in humanized MHC- dKO NOG mice.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	SCC-3 and Jurkat cells
	濃度	IC50 of 15 μM and 10 μM
	反応時間	4 days
	実験の流れ	Cells were treated with various concentrations of drug for 4 days.
動物実験	動物モデル	NOG-dKO mice
	投薬量	20 mg/kg
	投与方法	i.p.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Uncovering the colorectal cancer immunotherapeutic potential: Evening primrose (Oenothera biennis) root extract and its active compound oenothein B targeting the PD-1/PD-L1 blockade [ Phytomedicine, 2024, 125:155370]	PubMed: 38266440
Development and In Vivo Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1 [ J Med Chem, 2024, 67(5):4036-4062]	PubMed: 38442487
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design [ Comput Struct Biotechnol J, 2023, 21:3355-3368]	PubMed: 37384351
Turning a Tumor Microenvironment Pitfall into Opportunity: Discovery of Benzamidoxime as PD-L1 Ligand with pH-Dependent Potency [ Int J Mol Sci, 2023, 24(6)5535]	PubMed: 36982608
Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression [ J Vis Exp, 2023, (192).]	PubMed: 36806629
Whole-body PET tracking of a d-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors [ Acta Pharm Sin B, 2022, 12(3):1363-1376]	PubMed: 35530129
Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment [ J Immunother Cancer, 2022, 10(7)e004695]	PubMed: 35863821
Inhibition of PD-1 Alters the SHP1/2-PI3K/Akt Axis to Decrease M1 Polarization of Alveolar Macrophages in Lung Ischemia-Reperfusion Injury [ Inflammation, 2022, 10.1007/s10753-022-01762-6]	PubMed: 36357527
Near-Infrared Responsive Membrane Nanovesicles Amplify Homologous Targeting Delivery of Anti-PD Immunotherapy against Metastatic Tumors [ Adv Healthc Mater, 2021, e2101496]	PubMed: 34878725
Thermal-sensitive lipid nanoparticles potentiate anti-PD therapy through enhancing drug penetration and T lymphocytes infiltration in metastatic tumor [ Cancer Lett, 2021, 522:238-254]	PubMed: 34571084

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。