Pentoxifylline

製品コードS4345 バッチS434502

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C13H18N4O3
分子量 278.31 CAS No. 6493-05-6
Solubility (25°C)* 体外 DMSO 55 mg/mL (197.62 mM)
Water 55 mg/mL (197.62 mM)
Ethanol 55 mg/mL (197.62 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.
in vitro Pentoxifylline exhibits synergism with CDDP in killing MCF-7/E6 cells but does not affect sensitivity of the control cells. Pentoxifylline inhibits G2 checkpoint function to a greater extent in MCF-7/E6 than in the parental cells. [1] Pentoxifylline acts primarily by increasing red blood cell deformability, by reducing blood viscosity and by decreasing the potential for platelet aggregation and thrombus formation. [2] Pentoxifylline is efficacious in suppressing LPS-induced MO-derived TNF at the level of both TNF mRNA accumulation and TNF supernatant bioactivity. Pentoxifylline (10 μM) suppresses the production of both biologically active TNF and TNF mRNA expression by more than 50% in LM cells. [3] Pentoxifylline blocks cachectin/TNF mRNA accumulation but has no effect upon the efficiency of reporter mRNA translation in RAW 264.7 macrophages. Pentoxifylline combined with Dexamethasone causes a greater suppression of cachectin/TNF biosynthesis that can be achieved by either agent alone in RAW 264.7 macrophages. [4]
in vivo Pentoxifylline (500 mg) markedly inhibits increases in the serum levels of TNF and IL-6, as well as the effects on coagulation and fibrinolysis, in chimpanzees. Pentoxifylline (500 mg) along with Endotoxin (4 ng/kg) also has a significant effect on thrombin generation in chimpanzees. [5]

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable [ Antiviral Res, 2023, 216:105674] PubMed: 37459896
Repurposing FDA-approved drugs for anti-aging therapies. [ Biogerontology, 2016, 17(5-6):907-920] PubMed: 27484416

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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